Literature DB >> 14576133

Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines.

Teresa Krakauer1, Marilyn Buckley.   

Abstract

Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). Doxycycline inhibited SE-stimulated T-cell proliferation and production of cytokines and chemokines by human peripheral blood mononuclear cells. These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE.

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Year:  2003        PMID： 14576133      PMCID： PMC253774          DOI： 10.1128/AAC.47.11.3630-3633.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

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7.  Inhibition of matrix metalloproteinase-9 activity improves coronary outcome in an animal model of Kawasaki disease.

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8.  Protective effects of doxycycline in ischemia/reperfusion injury on kidney.

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10.  Periodontitis in rats induces systemic oxidative stress that is controlled by bone-targeted antiresorptives.

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