Piyaporn Karuwanarint1, Benjaluck Phonrat2, Anchalee Tungtrongchitr3, Kanjana Suriyaprom4, Somlak Chuengsamarn5, Florian J Schweigert6, Rungsunn Tungtrongchitr1. 1. Department of Tropical Nutrition & Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. 2. Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. 3. Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. 4. Faculty of Medical Technology, Rangsit University, Pathumthani, Thailand. 5. Division of Endocrinology & Metabolism, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center Srinakharinwirot University, Nakornnayok, Thailand. 6. Institute of Nutrition Science, Department of Physiology & Pathophysiology of Nutrition, University of Potsdam, Germany.
Abstract
AIM: To investigate the relationship of vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. MATERIALS & METHODS: GC-globulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. RESULTS: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-type (odds ratio: 3.25; p = 0.004). CONCLUSION: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais.
AIM: To investigate the relationship of vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. MATERIALS & METHODS: GC-globulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. RESULTS: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-type (odds ratio: 3.25; p = 0.004). CONCLUSION: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais.