E Delvin1, N Alos2, F Rauch3, V Marcil4, S Morel5, M Boisvert5, M-A Lecours5, C Laverdière2, D Sinnett2, M Krajinovic2, J Dubois6, S Drouin5, G Lefebvre7, M Samoilenko7, C Nyalendo8, E Cavalier9, E Levy4. 1. Sainte-Justine UHC Research Centre, Canada; Department of Biochemistry and Molecular Medicine, Université de Montréal, Canada. Electronic address: delvine@sympatico.ca. 2. Sainte-Justine UHC Research Centre, Canada; Department of Pediatrics, Université de Montréal, Canada. 3. Shriners Hospital for Children, Canada; McGill University Health Centre Research Institute, McGill University, Montreal, Canada. 4. Sainte-Justine UHC Research Centre, Canada; Department of Nutrition, Université de Montréal, Canada. 5. Sainte-Justine UHC Research Centre, Canada. 6. Sainte-Justine UHC Research Centre, Canada; Department of Radiology, Université de Montréal, Canada. 7. Department of Mathematics, Université du Québec à Montréal, Canada. 8. Sainte-Justine UHC Research Centre, Canada; Department of Clinical Biochemistry, Sainte-Justine UHC, Université de Montréal, Montréal, Canada. 9. Department of Clinical Chemistry, Université de Liège, CHU Sart-Tilman, Liège, Belgium.
Abstract
BACKGROUND: The remarkable progress in the treatment of childhood acute lymphoblastic leukemia (cALL) has led to a survival rate reaching 90%. This success story is unfortunately linked to increased risk of impaired skeletal mass accumulation during childhood and adolescence, predisposing the patients to osteoporosis and pathological fractures at adulthood. OBJECTIVE: This study aims at characterizing the vitamin D status and bone health biomarkers in a well-characterized cohort of cALL survivors. RESULTS: Food frequency questionnaires reveal that (i) the total vitamin D intake varies greatly (44-2132 IU/d), (ii) only 16.8% of the participants consume vitamin D supplements, and (iii) 74% of survivors' intakes are below the Recommended Daily Intakes (400 IU/d). For the 42 participants taking vitamin D supplements, the median (2.5-97.5%iles) intake is 600 IU/d (21.2-1972 IU/d). Sixteen participants are vitamin D deficient (<30 nM) and 66 insufficient (≥30 - <50 nM). Serum 24,25(OH)2D3 concentrations are directly related to those of 25OHD3, and those of 3-epi-25OHD3 below the Lower Limit of Quantification in most samples. The participants' serum concentrations of cross-linked C-telopeptide of type-I collagen and intact amino-terminal pro-peptide of type-I collagen decrease steadily with age, leveling at adulthood, and are at all times higher in males. CONCLUSION: The present study shows that the prevalence of vitamin D insufficiency or deficiency is not greater in cALL survivors compared to the general Canadian population despite low vitamin D food and supplement intakes. Furthermore, there seem to be no overt imbalance in the gender- and age-adjusted serum bone turnover marker concentrations.
BACKGROUND: The remarkable progress in the treatment of childhood acute lymphoblastic leukemia (cALL) has led to a survival rate reaching 90%. This success story is unfortunately linked to increased risk of impaired skeletal mass accumulation during childhood and adolescence, predisposing the patients to osteoporosis and pathological fractures at adulthood. OBJECTIVE: This study aims at characterizing the vitamin D status and bone health biomarkers in a well-characterized cohort of cALL survivors. RESULTS: Food frequency questionnaires reveal that (i) the total vitamin D intake varies greatly (44-2132 IU/d), (ii) only 16.8% of the participants consume vitamin D supplements, and (iii) 74% of survivors' intakes are below the Recommended Daily Intakes (400 IU/d). For the 42 participants taking vitamin D supplements, the median (2.5-97.5%iles) intake is 600 IU/d (21.2-1972 IU/d). Sixteen participants are vitamin D deficient (<30 nM) and 66 insufficient (≥30 - <50 nM). Serum 24,25(OH)2D3 concentrations are directly related to those of 25OHD3, and those of 3-epi-25OHD3 below the Lower Limit of Quantification in most samples. The participants' serum concentrations of cross-linked C-telopeptide of type-I collagen and intact amino-terminal pro-peptide of type-I collagen decrease steadily with age, leveling at adulthood, and are at all times higher in males. CONCLUSION: The present study shows that the prevalence of vitamin Dinsufficiency or deficiency is not greater in cALL survivors compared to the general Canadian population despite low vitamin D food and supplement intakes. Furthermore, there seem to be no overt imbalance in the gender- and age-adjusted serum bone turnover marker concentrations.
Authors: Laila M Sherief; Mohamed Beshir; Nermin Raafat; Elhamy R Abdelkhalek; Wesam A Mokhtar; Khaled M Elgerby; Basma K Soliman; Hosam E Salah; Ghada A Mokhtar; Naglaa M Kamal; Heba ELsayed; Marwa Zakaria Journal: Mol Genet Genomic Med Date: 2021-05-27 Impact factor: 2.183