Literature DB >> 2950183

Evidence for the involvement of endotoxin in toxic shock syndrome.

R L Stone, P M Schlievert.   

Abstract

The toxicity of toxic shock syndrome (TSS) toxin-1 (TSST-1) was evaluated in female, specific pathogen-free rabbits and conventional rabbits. Results after intravenous injections of TSST-1 given to both types of rabbits indicated that specific pathogen-free rabbits were resistant to the lethal effects observed in conventional rabbits. Lethality could be prevented by simultaneous administration of polymyxin B, and analysis of serum before and after dosing confirmed that dosing with TSST-1 resulted in circulating endotoxin. Analysis of sera from humans with TSS showed that endotoxin was present in acute-phase sera but not in convalescent-phase sera. These observations suggest that endogenous endotoxin contributes to rabbit susceptibility to TSST-1 and may play a role in human TSS.

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Year:  1987        PMID： 2950183     DOI： 10.1093/infdis/155.4.682

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  19 in total

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Authors:  B A Leonard; P M Schlievert
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4.  Pentoxifylline inhibits superantigen-induced toxic shock and cytokine release.

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Authors:  Teresa Krakauer; Stephen F Little; Bradley G Stiles
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6.  Human leukocyte antigen class II transgenic mouse model unmasks the significant extrahepatic pathology in toxic shock syndrome.

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7.  Proinflammatory mediators of toxic shock and their correlation to lethality.

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Review 8.  Models matter: the search for an effective Staphylococcus aureus vaccine.

Authors:  Wilmara Salgado-Pabón; Patrick M Schlievert
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9.  Toxicity of staphylococcal enterotoxins potentiated by lipopolysaccharide: major histocompatibility complex class II molecule dependency and cytokine release.

Authors:  B G Stiles; S Bavari; T Krakauer; R G Ulrich
Journal:  Infect Immun       Date:  1993-12       Impact factor: 3.441

10.  Biological activity of toxic shock syndrome toxin 1 and a site-directed mutant, H135A, in a lipopolysaccharide-potentiated mouse lethality model.

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Journal:  Infect Immun       Date:  1995-04       Impact factor: 3.441
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