Literature DB >> 16177395

Bacillus anthracis edema toxin inhibits Staphylococcus aureus enterotoxin B effects in vitro: a potential protein therapeutic?

Teresa Krakauer1, Stephen F Little, Bradley G Stiles.   

Abstract

Various in vitro effects of staphylococcal enterotoxin B (SEB) on human peripheral blood mononuclear cells were mitigated by Bacillus anthracis edema toxin. In particular, levels of some SEB-induced cytokines (tumor necrosis factor alpha, gamma interferon) and chemokines (monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha [MIP-1alpha], MIP-1beta) were significantly diminished or even nonexistent, depending upon the timing of edema toxin administration. Overall, these results suggest a novel use of B. anthracis edema toxin against a bacterial superantigen.

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Year:  2005        PMID： 16177395      PMCID： PMC1230970          DOI： 10.1128/IAI.73.10.7069-7073.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  36 in total

1.  Inhibition of bacterial superantigens by peptides and antibodies.

Authors:  K Visvanathan; A Charles; J Bannan; P Pugach; K Kashfi; J B Zabriskie
Journal:  Infect Immun       Date:  2001-02       Impact factor: 3.441

Review 2.  Chemokines: immunology's high impact factors.

Authors:  C R Mackay
Journal:  Nat Immunol       Date:  2001-02       Impact factor: 25.606

3.  Stoichiometry of anthrax toxin complexes.

Authors:  Jeremy Mogridge; Kristina Cunningham; R John Collier
Journal:  Biochemistry       Date:  2002-01-22       Impact factor: 3.162

Review 4.  Introduction: anthrax history, disease and ecology.

Authors:  P C B Turnbull
Journal:  Curr Top Microbiol Immunol       Date:  2002       Impact factor: 4.291

5.  Synergistic and antagonistic interactions between LPS and superantigens.

Authors:  Alexander H Dalpke; Klaus Heeg
Journal:  J Endotoxin Res       Date:  2003

6.  Bacillus anthracis oedema toxin as a cause of tissue necrosis and cell type-specific cytotoxicity.

Authors:  Daniel E Voth; Elaine E Hamm; Lan G Nguyen; Amy E Tucker; Isabelle I Salles; William Ortiz-Leduc; Jimmy D Ballard
Journal:  Cell Microbiol       Date:  2005-08       Impact factor: 3.715

7.  Staphylococcal enterotoxin A acts through nitric oxide synthase mechanisms in human peripheral blood mononuclear cells to stimulate synthesis of pyrogenic cytokines.

Authors:  S J Won; W T Huang; Y S Lai; M T Lin
Journal:  Infect Immun       Date:  2000-04       Impact factor: 3.441

8.  Pirfenidone blocks the in vitro and in vivo effects of staphylococcal enterotoxin B.

Authors:  Martha L Hale; Solomon B Margolin; Teresa Krakauer; Chad J Roy; Bradley G Stiles
Journal:  Infect Immun       Date:  2002-06       Impact factor: 3.441

Review 9.  Anthrax toxin: structures, functions and tumour targeting.

Authors:  Shihui Liu; Rebecca L Schubert; Thomas H Bugge; Stephen H Leppla
Journal:  Expert Opin Biol Ther       Date:  2003-08       Impact factor: 4.388

10.  Anthrax edema toxin requires influx of calcium for inducing cyclic AMP toxicity in target cells.

Authors:  Praveen Kumar; Nidhi Ahuja; Rakesh Bhatnagar
Journal:  Infect Immun       Date:  2002-09       Impact factor: 3.441
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  2 in total

1.  Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model.

Authors:  Caitlin W Hicks; Yan Li; Shu Okugawa; Steven B Solomon; Mahtab Moayeri; Stephen H Leppla; Ajana Mohanty; G Mani Subramanian; Thi S Mignone; Yvonne Fitz; Xizhong Cui; Peter Q Eichacker
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-01-07       Impact factor: 4.733

Review 2.  Lethal and edema toxins in the pathogenesis of Bacillus anthracis septic shock: implications for therapy.

Authors:  Kevin Sherer; Yan Li; Xizhong Cui; Peter Q Eichacker
Journal:  Am J Respir Crit Care Med       Date:  2006-11-09       Impact factor: 21.405
  2 in total

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