BACKGROUND: Single-nucleotide polymorphisms (SNPs) were discovered in HBV-related gestational diabetes mellitus, but it still unclear whether these SNPs are associated with the susceptibility of HBV-related gestational diabetes mellitus. METHODS: The investigation of the association between CDKN2A polymorphisms and occurrence of HBV-related gestational diabetes mellitus (GDM) in Chinese was assessed in the case-control study. A total of 480 pregnant patients with HBV and 530 pregnant controls were consecutively recruited from January 2015 to December 2016. Polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method was applied to measure genotyping for the detection of CDKN2A. RESULTS: The significant differences in the frequency of CDKN2A genotype distributions, rs10811661 and rs564398, were found by Chi-square test. Using conditional logistic analysis, individuals carrying the CDKN2A rs10811661 TC and TT genotypes and CDKN2A rs564398 AA and AG genotypes were related to a greater risk of HBV-related GDM compared with the genotype. CONCLUSIONS: In conclusion, the CDKN2A rs10811661 and rs564398 polymorphisms showed association with a greater risk of HBV-related GDM in a Chinese population.
BACKGROUND: Single-nucleotide polymorphisms (SNPs) were discovered in HBV-related gestational diabetes mellitus, but it still unclear whether these SNPs are associated with the susceptibility of HBV-related gestational diabetes mellitus. METHODS: The investigation of the association between CDKN2A polymorphisms and occurrence of HBV-related gestational diabetes mellitus (GDM) in Chinese was assessed in the case-control study. A total of 480 pregnant patients with HBV and 530 pregnant controls were consecutively recruited from January 2015 to December 2016. Polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method was applied to measure genotyping for the detection of CDKN2A. RESULTS: The significant differences in the frequency of CDKN2A genotype distributions, rs10811661 and rs564398, were found by Chi-square test. Using conditional logistic analysis, individuals carrying the CDKN2Ars10811661 TC and TT genotypes and CDKN2Ars564398 AA and AG genotypes were related to a greater risk of HBV-related GDM compared with the genotype. CONCLUSIONS: In conclusion, the CDKN2Ars10811661 and rs564398 polymorphisms showed association with a greater risk of HBV-related GDM in a Chinese population.
Authors: Stephen E Livingston; Josephine P Simonetti; Brian J McMahon; Lisa R Bulkow; Kathy J Hurlburt; Chriss E Homan; Mary M Snowball; Henry H Cagle; James L Williams; Vladimir P Chulanov Journal: J Infect Dis Date: 2006-11-21 Impact factor: 5.226