Sarah M Temkin1,2, Elise C Kohn3, Lynne Penberthy4, Kathleen A Cronin4, Lisa Rubinsak5, Lois A Dickie4, Lori Minasian6, Anne-Michelle Noone4. 1. Division of Gynecologic Oncology, Virginia Commonwealth University, Richmond, VA, USA. sarah.temkin@vcuhealth.org. 2. Department of Obstetrics and Gynecology, Virginia Commonwealth University, 1250 E Marshall Street, Main Hospital, Rm 8-206, Richmond, VA, 23298, USA. sarah.temkin@vcuhealth.org. 3. Cancer Therapy Evaluation Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 4. Division of Cancer Control & Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 5. Division of Gynecologic Oncology, Virginia Commonwealth University, Richmond, VA, USA. 6. Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Abstract
PURPOSE: This analysis describes the impact of hysterectomy on incidence rates and trends in endometrioid endometrial cancer in the United States among women of reproductive age. METHODS: Hysterectomy prevalence for states containing Surveillance, Epidemiology, and End Results (SEER) registry was estimated using data from the Behavioral Risk Factor Surveillance System (BRFSS) between 1992 and 2010. The population was adjusted for age, race, and calendar year strata. Age-adjusted incidence rates and trends of endometrial cancer among women age 20-49 corrected for hysterectomy were estimated. RESULTS: Hysterectomy prevalence varied by age, race, and ethnicity. Increasing incidence trends were observed, and were attenuated after correcting for hysterectomy. Among all women, the incidence was increasing 1.6% annually (95% CI 0.9, 2.3) and this increase was no longer significant after correction for hysterectomy (+ 0.7; 95% CI - 0.1, 1.5). Stage at diagnosis was similar with and without correction for hysterectomy. The largest increase in incidence over time was among Hispanic women; even after correction for hysterectomy, incidence was increasing (1.8%; 95% CI 0.2, 3.4) annually. CONCLUSION: Overall, endometrioid endometrial cancer incidence rates in the US remain stable among women of reproductive age. Routine reporting of endometrial cancer incidence does not accurately measure incidence among racial and ethnic minorities.
PURPOSE: This analysis describes the impact of hysterectomy on incidence rates and trends in endometrioid endometrial cancer in the United States among women of reproductive age. METHODS: Hysterectomy prevalence for states containing Surveillance, Epidemiology, and End Results (SEER) registry was estimated using data from the Behavioral Risk Factor Surveillance System (BRFSS) between 1992 and 2010. The population was adjusted for age, race, and calendar year strata. Age-adjusted incidence rates and trends of endometrial cancer among women age 20-49 corrected for hysterectomy were estimated. RESULTS: Hysterectomy prevalence varied by age, race, and ethnicity. Increasing incidence trends were observed, and were attenuated after correcting for hysterectomy. Among all women, the incidence was increasing 1.6% annually (95% CI 0.9, 2.3) and this increase was no longer significant after correction for hysterectomy (+ 0.7; 95% CI - 0.1, 1.5). Stage at diagnosis was similar with and without correction for hysterectomy. The largest increase in incidence over time was among Hispanic women; even after correction for hysterectomy, incidence was increasing (1.8%; 95% CI 0.2, 3.4) annually. CONCLUSION: Overall, endometrioid endometrial cancer incidence rates in the US remain stable among women of reproductive age. Routine reporting of endometrial cancer incidence does not accurately measure incidence among racial and ethnic minorities.
Entities:
Keywords:
Disparities; Endometrial cancer incidence; Hysterectomy
Authors: Kate T Simms; Susan Yuill; James Killen; Megan A Smith; Shalini Kulasingam; Inge M C M de Kok; Marjolein van Ballegooijen; Emily A Burger; Catherine Regan; Jane J Kim; Karen Canfell Journal: Gynecol Oncol Date: 2020-07-26 Impact factor: 5.482
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