Literature DB >> 29496415

Synthesis of enantiopure antiobesity drug lorcaserin.

Ivana Gazic Smilovic1, Jerome Cluzeau1, Frank Richter2, Sven Nerdinger3, Erwin Schreiner2, Gerhard Laus4, Herwig Schottenberger4.   

Abstract

Acylation of enantiomerically pure (R)-2-(3-chlorophenyl)propan-1-amine using chloroacetyl chloride, followed by borane reduction and aluminum chloride catalyzed cyclization yielded enantiopure lorcaserin.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  5-HT agonist; Enantiopure; Lorcaserin; Obesity

Mesh：

Substances：

Year:  2018        PMID： 29496415     DOI： 10.1016/j.bmc.2018.02.038

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  2 in total

1.  Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of γ-Fluoroamines.

Authors:  Giulia Roagna; David M H Ascough; Francesco Ibba; Anna Chiara Vicini; Alberto Fontana; Kirsten E Christensen; Aldo Peschiulli; Daniel Oehlrich; Antonio Misale; Andrés A Trabanco; Robert S Paton; Gabriele Pupo; Véronique Gouverneur
Journal:  J Am Chem Soc       Date:  2020-08-05       Impact factor: 15.419

2.  Synthesis of Chiral Tetrahydro-3-benzazepine Motifs by Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Ene-carbamates.

Authors:  Bram B C Peters; Pher G Andersson; Somsak Ruchirawat; Winai Ieawsuwan
Journal:  Org Lett       Date:  2022-03-03       Impact factor: 6.005
  2 in total

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