Liu Liu1,2, Shunping Li3,4, Yue Zhao5, Jianglin Zhang6, Gang Chen7. 1. School of Health Care Management, Shandong University, Jinan, China. 2. Key Laboratory of Health Economics and Policy Research, NHFPC (Shandong University), Jinan, China. 3. School of Health Care Management, Shandong University, Jinan, China. lishunping@sdu.edu.cn. 4. Key Laboratory of Health Economics and Policy Research, NHFPC (Shandong University), Jinan, China. lishunping@sdu.edu.cn. 5. Department of Dermatology, Heping Hospital, Changzhi Medical College, Changzhi, Shanxi, China. 6. Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China. 7. Centre for Health Economic, Monash Business School, Monash University, Melbourne, Australia.
Abstract
PURPOSE: To investigate the validity of direct and indirect health state utility (HSU) and subjective well-being measures in psoriasis vulgaris patients. METHODS: A convenience sampling framework was used to successively recruit patients with psoriasis vulgaris from the outpatient clinics of a tertiary hospital in Changsha, Central South China. Participants completed time trade-off (TTO), standard gamble (SG), the five-level EQ-5D (EQ-5D-5L), the WHO-5 well-being index, and the psoriasis disability index (PDI). The concurrent and known-groups validity of HSUs and well-being index in psoriasis patients were firstly studied. The agreements among HSUs and the relationship between HSU and well-being measures were further explored. RESULTS: A valid sample of 343 patients was analyzed. Mean HSU and well-being scores elicited from the EQ-5D-5L/TTO/SG and WHO-5 were 0.90/0.85/0.88 and 13.69, respectively. The Spearman correlation (concurrent validity) was the strongest between PDI and WHO-5 (r = 0.45), followed by with EQ-5D-5L (0.38), SG (r = 0.20), and the TTO (r = 0.18). The pairwise intraclass correlation coefficients among the three HSU measures were < 0.30. The known-groups validity was evident in all measures except for the SG. Exploratory factor analysis further suggests a complementary relationship between the EQ-5D-5L and WHO-5. CONCLUSIONS: There is a poor agreement between direct and indirect methods on measuring HSU with psoriasis vulgaris. Results from this study recommend that the EQ-5D-5L is the most preferred method to elicit HSU from psoriasis vulgaris patients in mainland China. It is important to further analyze the subjective well-being in addition to the HSU to fully understand the impact of psoriasis.
PURPOSE: To investigate the validity of direct and indirect health state utility (HSU) and subjective well-being measures in psoriasis vulgarispatients. METHODS: A convenience sampling framework was used to successively recruit patients with psoriasis vulgaris from the outpatient clinics of a tertiary hospital in Changsha, Central South China. Participants completed time trade-off (TTO), standard gamble (SG), the five-level EQ-5D (EQ-5D-5L), the WHO-5 well-being index, and the psoriasis disability index (PDI). The concurrent and known-groups validity of HSUs and well-being index in psoriasispatients were firstly studied. The agreements among HSUs and the relationship between HSU and well-being measures were further explored. RESULTS: A valid sample of 343 patients was analyzed. Mean HSU and well-being scores elicited from the EQ-5D-5L/TTO/SG and WHO-5 were 0.90/0.85/0.88 and 13.69, respectively. The Spearman correlation (concurrent validity) was the strongest between PDI and WHO-5 (r = 0.45), followed by with EQ-5D-5L (0.38), SG (r = 0.20), and the TTO (r = 0.18). The pairwise intraclass correlation coefficients among the three HSU measures were < 0.30. The known-groups validity was evident in all measures except for the SG. Exploratory factor analysis further suggests a complementary relationship between the EQ-5D-5L and WHO-5. CONCLUSIONS: There is a poor agreement between direct and indirect methods on measuring HSU with psoriasis vulgaris. Results from this study recommend that the EQ-5D-5L is the most preferred method to elicit HSU from psoriasis vulgarispatients in mainland China. It is important to further analyze the subjective well-being in addition to the HSU to fully understand the impact of psoriasis.
Entities:
Keywords:
EQ-5D-5L; Health state utility; Psoriasis vulgaris; Standard gamble; Time trade-off; Well-being
Authors: Susan Clemens; Nelufa Begum; Catherine Harper; Jennifer A Whitty; Paul A Scuffham Journal: Qual Life Res Date: 2014-03-28 Impact factor: 4.147