| Literature DB >> 29492671 |
Fengyuan Piao1, Rana Muhammad Aadil2, Raheel Suleman3, Kaixin Li4, Mengren Zhang4, Pingan Wu4, Muhammad Shahbaz5, Zulfiqar Ahmed6.
Abstract
Diets in rats and humans have shown promising results. Taurine improved glucagon activity, promoted glycemic stability, modified glucose levels, successfully addressed hyperglycemia via advanced glycation end-product control, improved insulin secretion and had a beneficial effect on insulin resistance. Taurine treatment performed well against oxidative stress in brain, increased the secretion of required hormones and protected against neuropathy, retinopathy and nephropathy in diabetes compared with the control. Taurine has been observed to be effective in treatments against diabetic hepatotoxicity, vascular problems and heart injury in diabetes. Taurine was shown to be effective against oxidative stress. The mechanism of action of taurine cannot be explained by one pathway, as it has many effects. Several of the pathways are the advanced glycation end-product pathway, PI3-kinase/AKT pathway and mitochondrial apoptosis pathway. The worldwide threat of diabetes underscores the urgent need for novel therapeutic measures against this disorder. Taurine (2-aminoethane sulfonic acid) is a natural compound that has been studied in diabetes and diabetes-induced complications.Entities:
Keywords: Diabetes; Nephropathy; Neuropathy; Retinopathy; Taurine
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Year: 2018 PMID： 29492671 DOI： 10.1007/s00726-018-2544-4
Source DB: PubMed Journal: Amino Acids ISSN： 0939-4451 Impact factor: 3.520