Mio Yanagisawa1, Alicia A Gingrich1, Sean Judge1, Chin-Shang Li2, Nana Wang3, Steven W Thorpe4, Amanda R Kirane1, Richard J Bold1, Arta M Monjazeb5, Robert J Canter6. 1. Division of Surgical Oncology, Department of Surgery, UC Davis School of Medicine, Sacramento, CA, U.S.A. 2. Department of Public Health Sciences, Division of Biostatistics, University of California, Davis, CA, U.S.A. 3. Department of Statistics, University of California, Davis, CA, U.S.A. 4. Department of Orthopedic Surgery, UC Davis School of Medicine, Sacramento, CA, U.S.A. 5. Department of Radiation Oncology, UC Davis School of Medicine, Sacramento, CA, U.S.A. 6. Division of Surgical Oncology, Department of Surgery, UC Davis School of Medicine, Sacramento, CA, U.S.A. rjcanter@ucdavis.edu.
Abstract
BACKGROUND/AIM: The predictive value of serum C-reactive protein (CRP) and neutrophil/lymphocyte (N/L) ratio in soft tissue sarcoma (STS) patients receiving neoadjuvant radiotherapy (RT) has not been analyzed. PATIENTS AND METHODS: From 2007 to 2015, we identified 98 STS patients from a prospective database. Using multivariate analysis, we analyzed CRP and N/L ratios as predictors of overall survival (OS). RESULTS: Mean age of patients was 59 years, 46% were female, and 55% of tumors were located at the extremity. A total of 15 histologies were represented. Fifty percent received preoperative RT. Except for extremity location, characteristics were similar between the preoperative RT and upfront surgery cohorts, including baseline CRP levels and N/L ratios. Multivariate analysis of upfront surgery revealed histological grade, tumor size, and baseline N/L ratio to be predictors of OS, while for preoperative RT, baseline CRP and N/L ratio were not predictive. CONCLUSION: Baseline CRP and N/L ratio did not predict poor clinical outcome in STS patients receiving neoadjuvant RT. Copyright
BACKGROUND/AIM: The predictive value of serum C-reactive protein (CRP) and neutrophil/lymphocyte (N/L) ratio in soft tissue sarcoma (STS) patients receiving neoadjuvant radiotherapy (RT) has not been analyzed. PATIENTS AND METHODS: From 2007 to 2015, we identified 98 STS patients from a prospective database. Using multivariate analysis, we analyzed CRP and N/L ratios as predictors of overall survival (OS). RESULTS: Mean age of patients was 59 years, 46% were female, and 55% of tumors were located at the extremity. A total of 15 histologies were represented. Fifty percent received preoperative RT. Except for extremity location, characteristics were similar between the preoperative RT and upfront surgery cohorts, including baseline CRP levels and N/L ratios. Multivariate analysis of upfront surgery revealed histological grade, tumor size, and baseline N/L ratio to be predictors of OS, while for preoperative RT, baseline CRP and N/L ratio were not predictive. CONCLUSION: Baseline CRP and N/L ratio did not predict poor clinical outcome in STS patients receiving neoadjuvant RT. Copyright
Authors: Dhruvil Shah; Dariusz Borys; Steve R Martinez; Chin-Shang Li; Robert M Tamurian; Richard J Bold; Arta Monjazeb; Robert J Canter Journal: Anticancer Res Date: 2012-09 Impact factor: 2.480
Authors: Robert J Canter; Dariusz Borys; Abimbola Olusanya; Chin-Shang Li; Li-Yuan Lee; Robert D Boutin; Scott D Christensen; Robert M Tamurian; Arta M Monjazeb Journal: Ann Surg Oncol Date: 2014-02-20 Impact factor: 5.344