| Literature DB >> 29489361 |
Cai-Juan Zheng1, Meng Bai1, Xue-Ming Zhou1, Guo-Lei Huang1, Tai-Ming Shao2, You-Ping Luo1, Zhi-Gang Niu1, Yan-Yan Niu1, Guang-Ying Chen1, Chang-Ri Han2.
Abstract
Three new indole diterpenes, penicilindoles A-C (1-3), were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their planar structures and absolute configurations were determined by interpretation of NMR spectroscopic data, HR-ESIMS, and X-ray diffraction analysis using Cu Kα radiation. The cytotoxic and antibacterial activities were evaluated in vitro; penicilindole A (1) showed cytotoxic activity against human A549 and HepG2 cell lines with IC50 values of 5.5 and 1.5 μM, respectively.Entities:
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Year: 2018 PMID： 29489361 DOI： 10.1021/acs.jnatprod.7b00673
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050