Literature DB >> 29487897

Cellular quiescence: How TGFβ protects cancer cells from chemotherapy.

Jessie A Brown1,2, Markus Schober1,3,2.   

Abstract

Using a functional proliferation reporter we identified quiescent tumor propagating cancer cells (TPCs) in intact squamous cell carcinomas, and found that TGFβ signaling controls their reversible entry into a growth arrested state, which protects TPCs from chemotherapy. TPCs with compromised TGFβ/Smad signaling can't enter quiescence and subsequently die from chemotherapy.

Entities:  

Keywords:  TGFβ; cancer stem cells; cell cycle; chemotherapy; quiescence; resistance; skin; squamous cell carcinoma; tumor heterogeneity; tumor propagating cells

Year:  2018        PMID： 29487897      PMCID： PMC5821413          DOI： 10.1080/23723556.2017.1413495

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Defining the epithelial stem cell niche in skin.

Authors:  Tudorita Tumbar; Geraldine Guasch; Valentina Greco; Cedric Blanpain; William E Lowry; Michael Rendl; Elaine Fuchs
Journal:  Science       Date:  2003-12-11       Impact factor: 47.728

2.  Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling.

Authors:  Markus Schober; Elaine Fuchs
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-13       Impact factor: 11.205

Review 3.  Squamous Cell Cancers: A Unified Perspective on Biology and Genetics.

Authors:  G Paolo Dotto; Anil K Rustgi
Journal:  Cancer Cell       Date:  2016-05-09       Impact factor: 31.743

4.  Differentiation of malignant to benign cells.

Authors:  G B Pierce; C Wallace
Journal:  Cancer Res       Date:  1971-02       Impact factor: 12.701

5.  Enrichment for murine keratinocyte stem cells based on cell surface phenotype.

Authors:  H Tani; R J Morris; P Kaur
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-26       Impact factor: 11.205

Review 6.  5-fluorouracil: mechanisms of action and clinical strategies.

Authors:  Daniel B Longley; D Paul Harkin; Patrick G Johnston
Journal:  Nat Rev Cancer       Date:  2003-05       Impact factor: 60.716

7.  TGF-β-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma.

Authors:  Jessie A Brown; Yoshiya Yonekubo; Nicole Hanson; Ana Sastre-Perona; Alice Basin; Julie A Rytlewski; Igor Dolgalev; Shane Meehan; Aristotelis Tsirigos; Slobodan Beronja; Markus Schober
Journal:  Cell Stem Cell       Date:  2017-11-02       Impact factor: 24.633

8.  Comprehensive genomic characterization of head and neck squamous cell carcinomas.

Authors: 
Journal:  Nature       Date:  2015-01-29       Impact factor: 49.962

Review 9.  Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy.

Authors:  Wanyin Chen; Jihu Dong; Jacques Haiech; Marie-Claude Kilhoffer; Maria Zeniou
Journal:  Stem Cells Int       Date:  2016-06-21       Impact factor: 5.443

10.  SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma.

Authors:  Jasmin M Siegle; Alice Basin; Ana Sastre-Perona; Yoshiya Yonekubo; Jessie Brown; Rachel Sennett; Michael Rendl; Aristotelis Tsirigos; John A Carucci; Markus Schober
Journal:  Nat Commun       Date:  2014-07-31       Impact factor: 14.919
  10 in total
  1 in total

1.  Cancer cell states and emergent properties of the dynamic tumor system.

Authors:  Dalia Barkley; Anjali Rao; Maayan Pour; Gustavo S França; Itai Yanai
Journal:  Genome Res       Date:  2021-10       Impact factor: 9.438
  1 in total

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