Literature DB >> 12724731

5-fluorouracil: mechanisms of action and clinical strategies.

Daniel B Longley1, D Paul Harkin, Patrick G Johnston.   

Abstract

5-fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant limitation to the clinical use of 5-FU. Emerging technologies, such as DNA microarray profiling, have the potential to identify novel genes that are involved in mediating resistance to 5-FU. Such target genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to 5-FU-based chemotherapy.

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Year:  2003        PMID： 12724731     DOI： 10.1038/nrc1074

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  1278 in total

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Journal:  Br J Pharmacol       Date:  2015-01-13       Impact factor: 8.739

2.  Anticancer effects of 5-fluorouracil combined with warming and relieving cold phlegm formula on human breast cancer.

Authors:  Xue-Lin Wang; Feng Ma; Xiong-Zhi Wu
Journal:  Chin J Integr Med       Date:  2011-12-08       Impact factor: 1.978

3.  Chemosensitization of cancer cells via gold nanoparticle-induced cell cycle regulation.

Authors:  Megan A Mackey; Mostafa A El-Sayed
Journal:  Photochem Photobiol       Date:  2014-02-11       Impact factor: 3.421

4.  Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues.

Authors:  Matthew A Schaich; Mallory R Smith; Ashley S Cloud; Sean M Holloran; Bret D Freudenthal
Journal:  Chem Res Toxicol       Date:  2017-09-01       Impact factor: 3.739

5.  Alteration of Drug Sensitivity in Human Colon Cancer Cells after Exposure to Heat: Implications for Liver Metastasis Therapy using RFA and Chemotherapy.

Authors:  Ryouji Makizumi; Weng-Lang Yang; Randall P Owen; Rohit R Sharma; T S Ravikumar
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6.  Multi-Domain Photopatterned 3D Tumor Constructs in a Micro-Physiological System for Analysis, Quantification, and Isolation of Infiltrating Cells.

Authors:  Shiny A P Rajan; Aleksander Skardal; Adam R Hall
Journal:  Adv Biosyst       Date:  2020-02-25

Review 7.  Polymeric nanoparticles-based topical delivery systems for the treatment of dermatological diseases.

Authors:  Zheng Zhang; Pei-Chin Tsai; Tannaz Ramezanli; Bozena B Michniak-Kohn
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2013-02-05

8.  High glucose modulates antiproliferative effect and cytotoxicity of 5-fluorouracil in human colon cancer cells.

Authors:  Yi-Shing Ma; I-Ping Yang; Hsiang-Lin Tsai; Ching-Wen Huang; Suh-Hang Hank Juo; Jaw-Yuan Wang
Journal:  DNA Cell Biol       Date:  2013-11-27       Impact factor: 3.311

Review 9.  Modulation of oxidative stress as an anticancer strategy.

Authors:  Chiara Gorrini; Isaac S Harris; Tak W Mak
Journal:  Nat Rev Drug Discov       Date:  2013-12       Impact factor: 84.694

10.  In vitro and in vivo evaluation of lipofufol, a new triple stealth liposomal formulation of modulated 5-fu: impact on efficacy and toxicity.

Authors:  Raphaelle Fanciullino; Séverine Mollard; Sarah Giacometti; Yael Berda-Haddad; Mohamed Chefrour; Claude Aubert; Athanassios Iliadis; Joseph Ciccolini
Journal:  Pharm Res       Date:  2013-02-06       Impact factor: 4.200
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