Literature DB >> 29487894

Autophagy and mitophagy in hepatocarcinogenesis.

Kai Liu1,2,3, Jiyoung Lee1, Jing-Hsiung James Ou1.   

Abstract

Autophagy is required for benign hepatic tumors to progress into malignant hepatocellular carcinoma. In our recent studies, we found that autophagy, or more specifically mitophagy, was required to suppress TP53 and induce the expression of the transcription factor NANOG to maintain hepatic cancer stem cells and promote hepatocarcinogenesis.

Entities:  

Keywords:  Autophagy; NANOG; PINK1; cancer stem cells; hepatocarcinogenesis; mitophagy; p53

Year:  2018        PMID： 29487894      PMCID： PMC5821411          DOI： 10.1080/23723556.2017.1405142

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  7 in total

Review 1.  Mechanisms of mitophagy.

Authors:  Richard J Youle; Derek P Narendra
Journal:  Nat Rev Mol Cell Biol       Date:  2011-01       Impact factor: 94.444

2.  Autophagy-deficient mice develop multiple liver tumors.

Authors:  Akito Takamura; Masaaki Komatsu; Taichi Hara; Ayako Sakamoto; Chieko Kishi; Satoshi Waguri; Yoshinobu Eishi; Okio Hino; Keiji Tanaka; Noboru Mizushima
Journal:  Genes Dev       Date:  2011-04-15       Impact factor: 11.361

Review 3.  Mitophagy mechanisms and role in human diseases.

Authors:  Matthew Redmann; Matthew Dodson; Michaël Boyer-Guittaut; Victor Darley-Usmar; Jianhua Zhang
Journal:  Int J Biochem Cell Biol       Date:  2014-05-16       Impact factor: 5.085

4.  Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells.

Authors:  Kai Liu; Jiyoung Lee; Ja Yeon Kim; Linya Wang; Yongjun Tian; Stephanie T Chan; Cecilia Cho; Keigo Machida; Dexi Chen; Jing-Hsiung James Ou
Journal:  Mol Cell       Date:  2017-10-12       Impact factor: 17.970

5.  Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis.

Authors:  Y Tian; C-F Kuo; D Sir; L Wang; S Govindarajan; L M Petrovic; J-H J Ou
Journal:  Cell Death Differ       Date:  2014-12-19       Impact factor: 15.828

6.  CD133+ cells with cancer stem cell characteristics associates with vasculogenic mimicry in triple-negative breast cancer.

Authors:  T J Liu; B C Sun; X L Zhao; X M Zhao; T Sun; Q Gu; Z Yao; X Y Dong; N Zhao; N Liu
Journal:  Oncogene       Date:  2012-04-02       Impact factor: 9.867

7.  TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice.

Authors:  Dinesh Babu Uthaya Kumar; Chia-Lin Chen; Jian-Chang Liu; Douglas E Feldman; Linda S Sher; Samuel French; Joseph DiNorcia; Samuel W French; Bita V Naini; Sunhawit Junrungsee; Vatche Garen Agopian; Ali Zarrinpar; Keigo Machida
Journal:  Gastroenterology       Date:  2015-11-12       Impact factor: 22.682
  7 in total
  4 in total

Review 1.  Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma.

Authors:  Fang Huang; Bing-Rong Wang; Yi-Gang Wang
Journal:  World J Gastroenterol       Date:  2018-11-07       Impact factor: 5.742

Review 2.  Autophagy represses hepatic carcinogenesis.

Authors:  Juliette Paillet; Guido Kroemer
Journal:  Mol Cell Oncol       Date:  2019-05-13

Review 3.  Cell Death in Hepatocellular Carcinoma: Pathogenesis and Therapeutic Opportunities.

Authors:  Ester García-Pras; Anabel Fernández-Iglesias; Jordi Gracia-Sancho; Sofía Pérez-Del-Pulgar
Journal:  Cancers (Basel)       Date:  2021-12-23       Impact factor: 6.639

4.  Identification of Autophagy-Related Genes and Small-Molecule Drugs in Esophageal Carcinoma.

Authors:  Zhenhua Li; Keqin Dong; Peiyuan Guo; Zirui Tan; Fan Zhang; Yang Tian; Huilai Lv
Journal:  Med Sci Monit       Date:  2020-05-16
  4 in total

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