Gauri Desai1, Gabriel Barg2, Elena I Queirolo3, Marie Vahter4, Fabiana Peregalli3, Nelly Mañay5, Katarzyna Kordas6. 1. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, The State University of New York (SUNY) at Buffalo, NY, USA. Electronic address: gauriabh@buffalo.edu. 2. Department of Neurocognition, Catholic University of Uruguay, Montevideo, Uruguay. 3. Center for Research, Catholic University of Uruguay, Montevideo, Uruguay. 4. Karolinska Institutet, Stockholm, Sweden. 5. Faculty of Chemistry, University of the Republic of Uruguay, Montevideo, Uruguay. 6. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, The State University of New York (SUNY) at Buffalo, NY, USA.
Abstract
BACKGROUND: Few studies have evaluated the association between low-level arsenic (As) exposure and cognitive performance among children. OBJECTIVES: In this cross-sectional study, we assessed the association between low-level As exposure and cognitive performance among 5-8 year-old children in Montevideo, and tested effect modification by As methylation capacity and children's dietary folate intake. METHODS: We measured total urinary As (UAs) concentrations and the proportion of monomethylarsonic acid (MMA) in the urine of 328 children. Seven subtests of the standardized Woodcock-Muñoz cognitive battery were used to assess cognitive performance, from which, the general intellectual abilities (GIA) score was derived. Total folate intake was estimated from two 24-h dietary recalls. Linear regression analyses were performed. Effect modification was assessed by stratifying at the median %MMA value and tertiles of total folate intake calculated as micrograms (µg) of dietary folate equivalents (dfe). RESULTS: The median UAs was 11.9 µg/l (range = 1.4-93.9), mean folate intake was 337.4 (SD = 123.3) µg dfe, and median %MMA was 9.42 (range = 2.6-24.8). There was no association between UAs and cognitive abilities, and no consistent effect modification by %MMA. UAs was associated inversely with concept formation, and positively with cognitive efficiency and numbers reversed subtest in the lowest folate intake tertile; UAs was also positively associated with sound integration in the second tertile and concept formation in the highest tertile of folate intake. There was no consistent pattern of effect modification by %MMA or folate intake. CONCLUSION: There was no association between low-level As exposure and general cognitive abilities.
BACKGROUND: Few studies have evaluated the association between low-level arsenic (As) exposure and cognitive performance among children. OBJECTIVES: In this cross-sectional study, we assessed the association between low-level As exposure and cognitive performance among 5-8 year-old children in Montevideo, and tested effect modification by As methylation capacity and children's dietary folate intake. METHODS: We measured total urinary As (UAs) concentrations and the proportion of monomethylarsonic acid (MMA) in the urine of 328 children. Seven subtests of the standardized Woodcock-Muñoz cognitive battery were used to assess cognitive performance, from which, the general intellectual abilities (GIA) score was derived. Total folate intake was estimated from two 24-h dietary recalls. Linear regression analyses were performed. Effect modification was assessed by stratifying at the median %MMA value and tertiles of total folate intake calculated as micrograms (µg) of dietary folate equivalents (dfe). RESULTS: The median UAs was 11.9 µg/l (range = 1.4-93.9), mean folate intake was 337.4 (SD = 123.3) µg dfe, and median %MMA was 9.42 (range = 2.6-24.8). There was no association between UAs and cognitive abilities, and no consistent effect modification by %MMA. UAs was associated inversely with concept formation, and positively with cognitive efficiency and numbers reversed subtest in the lowest folate intake tertile; UAs was also positively associated with sound integration in the second tertile and concept formation in the highest tertile of folate intake. There was no consistent pattern of effect modification by %MMA or folate intake. CONCLUSION: There was no association between low-level As exposure and general cognitive abilities.
Authors: J Calderón; M E Navarro; M E Jimenez-Capdeville; M A Santos-Diaz; A Golden; I Rodriguez-Leyva; V Borja-Aburto; F Díaz-Barriga Journal: Environ Res Date: 2001-02 Impact factor: 6.498
Authors: Brandilyn A Peters; Megan N Hall; Xinhua Liu; Faruque Parvez; Tiffany R Sanchez; Alexander van Geen; Jacob L Mey; Abu B Siddique; Hasan Shahriar; Mohammad Nasir Uddin; Tariqul Islam; Olgica Balac; Vesna Ilievski; Pam Factor-Litvak; Joseph H Graziano; Mary V Gamble Journal: Environ Health Perspect Date: 2015-05-15 Impact factor: 9.031
Authors: Seth Frndak; Gabriel Barg; Richard L Canfield; Elena I Quierolo; Nelly Mañay; Katarzyna Kordas Journal: Neurotoxicology Date: 2019-04-09 Impact factor: 4.294
Authors: Gauri Desai; Marie Vahter; Elena I Queirolo; Fabiana Peregalli; Nelly Mañay; Amy E Millen; Jihnhee Yu; Richard W Browne; Katarzyna Kordas Journal: J Nutr Date: 2020-05-01 Impact factor: 4.798
Authors: Sajin Bae; Elena Kamynina; Heather M Guetterman; Adetutu F Farinola; Marie A Caudill; Robert J Berry; Patricia A Cassano; Patrick J Stover Journal: Cochrane Database Syst Rev Date: 2021-10-18
Authors: Gauri Desai; Gabriel Barg; Marie Vahter; Elena I Queirolo; Fabiana Peregalli; Nelly Mañay; Amy E Millen; Jihnhee Yu; Richard W Browne; Katarzyna Kordas Journal: Int J Hyg Environ Health Date: 2019-10-03 Impact factor: 5.840
Authors: Gabriel Barg; Mónica Daleiro; Elena I Queirolo; Julia Ravenscroft; Nelly Mañay; Fabiana Peregalli; Katarzyna Kordas Journal: Int J Environ Res Public Health Date: 2018-12-04 Impact factor: 3.390
Authors: Antonio J Signes-Pastor; Megan E Romano; Brian Jackson; Joseph M Braun; Kimberly Yolton; Aimin Chen; Bruce Lanphear; Margaret R Karagas Journal: Int J Hyg Environ Health Date: 2022-08-07 Impact factor: 7.401
Authors: Marisa A Patti; Karl T Kelsey; Amanda J MacFarlane; George D Papandonatos; Tye E Arbuckle; Jillian Ashley-Martin; Mandy Fisher; William D Fraser; Bruce P Lanphear; Gina Muckle; Joseph M Braun Journal: Int J Environ Res Public Health Date: 2022-09-09 Impact factor: 4.614