| Literature DB >> 29478675 |
M Rhia L Stone1, Mark S Butler2, Wanida Phetsang3, Matthew A Cooper4, Mark A T Blaskovich5.
Abstract
Better understanding how multidrug-resistant (MDR) bacteria can evade current and novel antibiotics requires a better understanding of the chemical biology of antibiotic action. This necessitates using new tools and techniques to advance our knowledge of bacterial responses to antibiotics, ideally in live cells in real time, to selectively investigate bacterial growth, division, metabolism, and resistance in response to antibiotic challenge. In this review, we discuss the preparation and biological evaluation of fluorescent antibiotics, focussing on how these reporters and assay methods can help elucidate resistance mechanisms. We also examine the potential utility of such probes for real-time in vivo diagnosis of infections.Entities:
Keywords: antibiotics; bacteria; detection; diagnosis; fluorescent probes; infection imaging; mode of action
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Year: 2018 PMID： 29478675 DOI： 10.1016/j.tibtech.2018.01.004
Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536