| Literature DB >> 29477616 |
Katrin Parmar1, Christine Stadelmann2, Maria A Rocca3, Dawn Langdon4, Egidio D'Angelo5, Marcus D'Souza6, Jessica Burggraaff7, Christiane Wegner2, Jaume Sastre-Garriga8, Alonso Barrantes-Freer2, Jonas Dorn9, Bernard M J Uitdehaag7, Xavier Montalban8, Jens Wuerfel10, Christian Enzinger11, Alex Rovira12, Mar Tintore8, Massimo Filippi3, Ludwig Kappos13, Till Sprenger6.
Abstract
Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.Entities:
Keywords: Atrophy; Cerebellum; Cognition; Depth-sensing computer vision; Magnetic resonance imaging; Multiple sclerosis; Neurodegeneration
Mesh：
Year: 2018 PMID： 29477616 DOI： 10.1016/j.neubiorev.2018.02.012
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989