BACKGROUND: The cardiac electrical biomarker (CEB) is a novel electrocardiographic (ECG) marker quantifying the dipolar activity of the heart with higher levels indicating myocardial injury. METHODS: We prospectively enrolled 1097 patients presenting with suspected non-ST-elevation myocardial infarction (NSTEMI) to the emergency department (ED). Digital 12-lead ECGs were recorded at presentation and the CEB values were calculated in a blinded fashion. The final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all-cause mortality during 2 years of follow-up. RESULTS: NSTEMI was the final diagnosis in 14% of patients. CEB levels were higher in patients with NSTEMI compared to other causes of chest pain (median 44 (IQR 21-98) vs. 30 (IQR 16-61), p < .001). A weak but significant correlation between levels of high-sensitivity cardiac troponin T (hs-cTnT) at admission to the ED and the CEB was found (r = .23, p < .001). The use of the CEB in addition to conventional ECG criteria improved the diagnostic accuracy for the diagnosis of NSTEMI as quantified by the area under the receiver operating characteristics curve from 0.66 to 0.71 (p < .001) and the sensitivity improved from 43% to 79% (p < .001). CONCLUSION: In conclusion, the CEB, an ECG marker of myocardial injury, significantly improves the accuracy and sensitivity of the ECG for the diagnosis of NSTEMI.
BACKGROUND: The cardiac electrical biomarker (CEB) is a novel electrocardiographic (ECG) marker quantifying the dipolar activity of the heart with higher levels indicating myocardial injury. METHODS: We prospectively enrolled 1097 patients presenting with suspected non-ST-elevation myocardial infarction (NSTEMI) to the emergency department (ED). Digital 12-lead ECGs were recorded at presentation and the CEB values were calculated in a blinded fashion. The final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all-cause mortality during 2 years of follow-up. RESULTS: NSTEMI was the final diagnosis in 14% of patients. CEB levels were higher in patients with NSTEMI compared to other causes of chest pain (median 44 (IQR 21-98) vs. 30 (IQR 16-61), p < .001). A weak but significant correlation between levels of high-sensitivity cardiac troponin T (hs-cTnT) at admission to the ED and the CEB was found (r = .23, p < .001). The use of the CEB in addition to conventional ECG criteria improved the diagnostic accuracy for the diagnosis of NSTEMI as quantified by the area under the receiver operating characteristics curve from 0.66 to 0.71 (p < .001) and the sensitivity improved from 43% to 79% (p < .001). CONCLUSION: In conclusion, the CEB, an ECG marker of myocardial injury, significantly improves the accuracy and sensitivity of the ECG for the diagnosis of NSTEMI.
Authors: Patrick M Bossuyt; Johannes B Reitsma; David E Bruns; Constantine A Gatsonis; Paul P Glasziou; Les M Irwig; David Moher; Drummond Rennie; Henrica C W de Vet; Jeroen G Lijmer Journal: Ann Intern Med Date: 2003-01-07 Impact factor: 25.391
Authors: Ivo Strebel; Raphael Twerenbold; Jasper Boeddinghaus; Roger Abächerli; Maria Rubini Giménez; Karin Wildi; Karin Grimm; Christian Puelacher; Patrick Badertscher; Zaid Sabti; Dominik Breitenbücher; Janina Jann; Farah Selman; Jeanne du Fay de Lavallaz; Nicolas Schaerli; Thomas Nestelberger; Claudia Stelzig; Michael Freese; Lukas Schumacher; Stefan Osswald; Christian Mueller; Tobias Reichlin Journal: Ann Noninvasive Electrocardiol Date: 2018-02-24 Impact factor: 1.468
Authors: Monika M Safford; Gaurav Parmar; Codrin S Barasch; Jewell H Halanych; Stephen P Glasser; David C Goff; Ronald J Prineas; Todd M Brown Journal: BMC Health Serv Res Date: 2013-05-01 Impact factor: 2.655
Authors: Ivo Strebel; Raphael Twerenbold; Jasper Boeddinghaus; Roger Abächerli; Maria Rubini Giménez; Karin Wildi; Karin Grimm; Christian Puelacher; Patrick Badertscher; Zaid Sabti; Dominik Breitenbücher; Janina Jann; Farah Selman; Jeanne du Fay de Lavallaz; Nicolas Schaerli; Thomas Nestelberger; Claudia Stelzig; Michael Freese; Lukas Schumacher; Stefan Osswald; Christian Mueller; Tobias Reichlin Journal: Ann Noninvasive Electrocardiol Date: 2018-02-24 Impact factor: 1.468