| Literature DB >> 29476184 |
Etienne Patin1,2,3, Milena Hasan4, Jacob Bergstedt5,6, Vincent Rouilly7,4, Valentina Libri4, Alejandra Urrutia4,8,9,10, Cécile Alanio4,8,9, Petar Scepanovic11,12, Christian Hammer11,12, Friederike Jönsson13,14, Benoît Beitz4, Hélène Quach15,16,7, Yoong Wearn Lim10, Julie Hunkapiller17, Magge Zepeda18, Cherie Green19, Barbara Piasecka15,16,7,4, Claire Leloup17, Lars Rogge4,20, François Huetz21,22, Isabelle Peguillet23,24, Olivier Lantz23,24,25,26, Magnus Fontes6,27, James P Di Santo4,9,28, Stéphanie Thomas4,8,9, Jacques Fellay10,11, Darragh Duffy4,8,9, Lluís Quintana-Murci15,16,7, Matthew L Albert29,30,31,32.
Abstract
The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelated people of Western European ancestry. We found that smoking, together with age, sex and latent infection with cytomegalovirus, were the main non-genetic factors that affected variation in parameters of human immune cells. Genome-wide association studies of 166 immunophenotypes identified 15 loci that showed enrichment for disease-associated variants. Finally, we demonstrated that the parameters of innate cells were more strongly controlled by genetic variation than were those of adaptive cells, which were driven by mainly environmental exposure. Our data establish a resource that will generate new hypotheses in immunology and highlight the role of innate immunity in susceptibility to common autoimmune diseases.Entities:
Mesh：
Year: 2018 PMID： 29476184 DOI： 10.1038/s41590-018-0049-7
Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606