Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Interaction of Trypanosoma cruzi adenylate cyclase with liver regulatory factors.

Literature DB >> 2947568

Interaction of Trypanosoma cruzi adenylate cyclase with liver regulatory factors.

C Eisenschlos, M M Flawiá, M Torruella, H N Torres.

Abstract

Trypanosoma cruzi adenylate cyclase catalytic subunits may interact with regulatory factors from rat liver membranes, reconstituting heterologous systems which are catalytically active in assay mixtures containing MgATP. The systems show stimulatory responses to glucagon and guanosine 5'-[beta gamma-imido]triphosphate (p[NH]ppG) or fluoride. Reconstitution was obtained by three different methods: fusion of rat liver membranes (pretreated with N-ethylmaleimide) to T. cruzi membranes; interaction of detergent extracts of rat liver membranes with T. cruzi membranes; or interaction of purified preparations of T. cruzi adenylate cyclase and of liver membrane factors in phospholipid vesicles. The liver factors responsible for the guanine nucleotide effect were characterized as the NS protein. Data also indicate that reconstitution requires the presence of a membrane substrate.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1986 PMID： 2947568 PMCID： PMC1146804 DOI： 10.1042/bj2360185

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

22 in total

1. G proteins and dual control of adenylate cyclase.

Authors: A G Gilman
Journal: Cell Date: 1984-03 Impact factor: 41.582

2. Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations.

Authors: D J Capon; P H Seeburg; J P McGrath; J S Hayflick; U Edman; A D Levinson; D V Goeddel
Journal: Nature Date: 1983 Aug 11-17 Impact factor: 49.962

3. Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene.

Authors: Y Yuasa; S K Srivastava; C Y Dunn; J S Rhim; E P Reddy; S A Aaronson
Journal: Nature Date: 1983-06-30 Impact factor: 49.962

4. Genetic analysis of yeast RAS1 and RAS2 genes.

Authors: T Kataoka; S Powers; C McGill; O Fasano; J Strathern; J Broach; M Wigler
Journal: Cell Date: 1984-06 Impact factor: 41.582

5. Comparative biochemical properties of normal and activated human ras p21 protein.

Authors: J P McGrath; D J Capon; D V Goeddel; A D Levinson
Journal: Nature Date: 1984 Aug 23-29 Impact factor: 49.962

6. The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity.

Authors: R W Sweet; S Yokoyama; T Kamata; J R Feramisco; M Rosenberg; M Gross
Journal: Nature Date: 1984 Sep 20-26 Impact factor: 49.962

7. Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins.

Authors: S Powers; T Kataoka; O Fasano; M Goldfarb; J Strathern; J Broach; M Wigler
Journal: Cell Date: 1984-03 Impact factor: 41.582

8. Reconstitution of a hormone-sensitive adenylate cyclase with membrane extracts from Neurospora and avian erythrocytes.

Authors: M M Flawiá; A R Kornblihtt; J A Reig; M Torruella; H N Torres
Journal: J Biol Chem Date: 1983-07-10 Impact factor: 5.157

Interaction of Trypanosoma cruzi adenylate cyclase with liver regulatory factors.

1. G proteins and dual control of adenylate cyclase.

2. Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations.

3. Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene.

4. Genetic analysis of yeast RAS1 and RAS2 genes.

5. Comparative biochemical properties of normal and activated human ras p21 protein.

6. The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity.

7. Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins.

8. Reconstitution of a hormone-sensitive adenylate cyclase with membrane extracts from Neurospora and avian erythrocytes.

9. Reconstitution of adenylate cyclase in Neurospora from two components of the enzyme.

10. Soluble adenylate cyclase activity in Neurospora crassa.

1. Evidence for the existence of an Ns-type regulatory protein in Trypanosoma cruzi membranes.

Review 2. Pathways of the evolution of hormonal signal realization systems.

Review 3. Molecular basis of transmembrane signal transduction in Dictyostelium discoideum.

4. G-protein from Medicago sativa: functional association to photoreceptors.

5. Regulation of ciliary adenylate cyclase by Ca2+ in Paramecium.