Literature DB >> 29475579

Taking Aim at Glycolysis with CDK8 Inhibitors.

Robert P Fisher1.   

Abstract

Dependence on glycolysis under aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  CDK8; Mediator; cancer; chemical genetics; glycolysis; transcription

Mesh：

Substances：

Year:  2018        PMID： 29475579      PMCID： PMC5911231          DOI： 10.1016/j.tem.2018.02.005

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  12 in total

1.  Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.

Authors:  Stéphane Larochelle; Karl A Merrick; Marie-Emilie Terret; Lara Wohlbold; Nora M Barboza; Chao Zhang; Kevan M Shokat; Prasad V Jallepalli; Robert P Fisher
Journal:  Mol Cell       Date:  2007-03-23       Impact factor: 17.970

Review 2.  Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

Authors:  Nissim Hay
Journal:  Nat Rev Cancer       Date:  2016-09-16       Impact factor: 60.716

3.  Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas.

Authors:  Bartlomiej Bartkowiak; Christopher Yan; Arno L Greenleaf
Journal:  Biochim Biophys Acta       Date:  2015-07-17

4.  HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

Authors:  Matthew D Galbraith; Mary A Allen; Claire L Bensard; Xiaoxing Wang; Marie K Schwinn; Bo Qin; Henry W Long; Danette L Daniels; William C Hahn; Robin D Dowell; Joaquín M Espinosa
Journal:  Cell       Date:  2013-06-06       Impact factor: 41.582

5.  A chemical switch for inhibitor-sensitive alleles of any protein kinase.

Authors:  A C Bishop; J A Ubersax; D T Petsch; D P Matheos; N S Gray; J Blethrow; E Shimizu; J Z Tsien; P G Schultz; M D Rose; J L Wood; D O Morgan; K M Shokat
Journal:  Nature       Date:  2000-09-21       Impact factor: 49.962

6.  CDK8 Kinase Activity Promotes Glycolysis.

Authors:  Matthew D Galbraith; Zdenek Andrysik; Ahwan Pandey; Maria Hoh; Elizabeth A Bonner; Amanda A Hill; Kelly D Sullivan; Joaquín M Espinosa
Journal:  Cell Rep       Date:  2017-11-07       Impact factor: 9.423

7.  Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.

Authors:  Sampada Kalan; Ramon Amat; Miriam Merzel Schachter; Nicholas Kwiatkowski; Brian J Abraham; Yanke Liang; Tinghu Zhang; Calla M Olson; Stéphane Larochelle; Richard A Young; Nathanael S Gray; Robert P Fisher
Journal:  Cell Rep       Date:  2017-10-10       Impact factor: 9.423

Review 8.  The Mediator complex: a central integrator of transcription.

Authors:  Benjamin L Allen; Dylan J Taatjes
Journal:  Nat Rev Mol Cell Biol       Date:  2015-02-18       Impact factor: 94.444

9.  Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

Authors:  Nicholas Kwiatkowski; Tinghu Zhang; Peter B Rahl; Brian J Abraham; Jessica Reddy; Scott B Ficarro; Anahita Dastur; Arnaud Amzallag; Sridhar Ramaswamy; Bethany Tesar; Catherine E Jenkins; Nancy M Hannett; Douglas McMillin; Takaomi Sanda; Taebo Sim; Nam Doo Kim; Thomas Look; Constantine S Mitsiades; Andrew P Weng; Jennifer R Brown; Cyril H Benes; Jarrod A Marto; Richard A Young; Nathanael S Gray
Journal:  Nature       Date:  2014-06-22       Impact factor: 49.962

10.  CDK9-dependent RNA polymerase II pausing controls transcription initiation.

Authors:  Saskia Gressel; Björn Schwalb; Tim Michael Decker; Weihua Qin; Heinrich Leonhardt; Dirk Eick; Patrick Cramer
Journal:  Elife       Date:  2017-10-10       Impact factor: 8.140
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  1 in total

Review 1.  Therapeutic targeting of transcriptional cyclin-dependent kinases.

Authors:  Matthew D Galbraith; Heather Bender; Joaquín M Espinosa
Journal:  Transcription       Date:  2018-11-09
  1 in total

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