Literature DB >> 27634447

Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

Nissim Hay1.   

Abstract

In recent years there has been a growing interest among cancer biologists in cancer metabolism. This Review summarizes past and recent advances in our understanding of the reprogramming of glucose metabolism in cancer cells, which is mediated by oncogenic drivers and by the undifferentiated character of cancer cells. The reprogrammed glucose metabolism in cancer cells is required to fulfil anabolic demands. This Review discusses the possibility of exploiting the reprogrammed glucose metabolism for therapeutic approaches that selectively target cancer cells.

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Year:  2016        PMID： 27634447      PMCID： PMC5516800          DOI： 10.1038/nrc.2016.77

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  131 in total

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Journal:  J Biol Chem       Date:  1997-07-25       Impact factor: 5.157

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Journal:  Science       Date:  1956-08-10       Impact factor: 47.728

3.  On the origin of cancer cells.

Authors:  O WARBURG
Journal:  Science       Date:  1956-02-24       Impact factor: 47.728

Review 4.  Pyruvate kinase: Function, regulation and role in cancer.

Authors:  William J Israelsen; Matthew G Vander Heiden
Journal:  Semin Cell Dev Biol       Date:  2015-08-13       Impact factor: 7.727

5.  High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy.

Authors:  Irina Gromova; Pavel Gromov; Naoko Honma; Sudha Kumar; David Rimm; Maj-Lis Møller Talman; Vera Timmermans Wielenga; José M A Moreira
Journal:  Mol Oncol       Date:  2015-05-14       Impact factor: 6.603

6.  Evidence for an alternative glycolytic pathway in rapidly proliferating cells.

Authors:  Matthew G Vander Heiden; Jason W Locasale; Kenneth D Swanson; Hadar Sharfi; Greg J Heffron; Daniel Amador-Noguez; Heather R Christofk; Gerhard Wagner; Joshua D Rabinowitz; John M Asara; Lewis C Cantley
Journal:  Science       Date:  2010-09-17       Impact factor: 47.728

Review 7.  MYC, Metabolism, and Cancer.

Authors:  Zachary E Stine; Zandra E Walton; Brian J Altman; Annie L Hsieh; Chi V Dang
Journal:  Cancer Discov       Date:  2015-09-17       Impact factor: 39.397

8.  Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

Authors:  Edouard Mullarky; Natasha C Lucki; Reza Beheshti Zavareh; Justin L Anglin; Ana P Gomes; Brandon N Nicolay; Jenny C Y Wong; Stefan Christen; Hidenori Takahashi; Pradeep K Singh; John Blenis; J David Warren; Sarah-Maria Fendt; John M Asara; Gina M DeNicola; Costas A Lyssiotis; Luke L Lairson; Lewis C Cantley
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-01       Impact factor: 11.205

9.  Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.

Authors:  Hai Hu; Ashish Juvekar; Costas A Lyssiotis; Evan C Lien; John G Albeck; Doogie Oh; Gopal Varma; Yin Pun Hung; Soumya Ullas; Josh Lauring; Pankaj Seth; Mark R Lundquist; Dean R Tolan; Aaron K Grant; Daniel J Needleman; John M Asara; Lewis C Cantley; Gerburg M Wulf
Journal:  Cell       Date:  2016-01-28       Impact factor: 41.582

10.  Suppression of gluconeogenic gene expression by LSD1-mediated histone demethylation.

Authors:  Dongning Pan; Chunxiao Mao; Yong-Xu Wang
Journal:  PLoS One       Date:  2013-06-05       Impact factor: 3.240
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  299 in total

Review 1.  Mitochondrial dynamics as regulators of cancer biology.

Authors:  Andrew Paul Trotta; Jerry Edward Chipuk
Journal:  Cell Mol Life Sci       Date:  2017-01-12       Impact factor: 9.261

2.  Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.

Authors:  Peiwei Huangyang; Fuming Li; Pearl Lee; Itzhak Nissim; Aalim M Weljie; Anthony Mancuso; Bo Li; Brian Keith; Sam S Yoon; M Celeste Simon
Journal:  Cell Metab       Date:  2019-11-21       Impact factor: 27.287

3.  Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer.

Authors:  Zhen Li; Jin Su; Mingming Sun; Jiaqi Song; Huanran Sun; Jun Fan; Guo Chen; Changliang Shan; Qi Qi; Shuai Zhang
Journal:  Mol Cell Biochem       Date:  2021-05-10       Impact factor: 3.396

4.  Cell forces meet cell metabolism.

Authors:  Tadamoto Isogai; Jin Suk Park; Gaudenz Danuser
Journal:  Nat Cell Biol       Date:  2017-05-31       Impact factor: 28.824

Review 5.  Probing carbohydrate metabolism using hyperpolarized 13 C-labeled molecules.

Authors:  Jaspal Singh; Eul Hyun Suh; Gaurav Sharma; Chalermchai Khemtong; A Dean Sherry; Zoltan Kovacs
Journal:  NMR Biomed       Date:  2018-11-26       Impact factor: 4.044

Review 6.  The role of RNA alternative splicing in regulating cancer metabolism.

Authors:  Itamar Kozlovski; Zahava Siegfried; Adi Amar-Schwartz; Rotem Karni
Journal:  Hum Genet       Date:  2017-04-20       Impact factor: 4.132

Review 7.  Revisiting the hallmarks of cancer.

Authors:  Yousef Ahmed Fouad; Carmen Aanei
Journal:  Am J Cancer Res       Date:  2017-05-01       Impact factor: 6.166

8.  Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells.

Authors:  Haobin Ye; Biniam Adane; Nabilah Khan; Erica Alexeev; Nichole Nusbacher; Mohammad Minhajuddin; Brett M Stevens; Amanda C Winters; Xi Lin; John M Ashton; Enkhtsetseg Purev; Lianping Xing; Daniel A Pollyea; Catherine A Lozupone; Natalie J Serkova; Sean P Colgan; Craig T Jordan
Journal:  Cancer Cell       Date:  2018-09-27       Impact factor: 31.743

Review 9.  Enzymatic and nonenzymatic protein acetylations control glycolysis process in liver diseases.

Authors:  Juan Li; Tongxin Wang; Jun Xia; Weilei Yao; Feiruo Huang
Journal:  FASEB J       Date:  2019-08-01       Impact factor: 5.191

10.  Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse.

Authors:  Alexandra Brito; Patrícia M R Pereira; Rui L Reis; Rein V Ulijn; Jason S Lewis; Ricardo A Pires; Iva Pashkuleva
Journal:  Nanoscale       Date:  2020-10-01       Impact factor: 7.790
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