Jung-Ha Kim1, Doan T Nguyen1, Jeremy T Booth2, Chen-Yu Huang1, Todsaporn Fuangrod3, Per Poulsen4, Ricky O'Brien1, Vincent Caillet5, Thomas Eade6, Andrew Kneebone6, Paul Keall7. 1. Radiation Physics Laboratory, Sydney Medical School, The University of Sydney, Australia. 2. Northern Sydney Cancer Centre, Royal North Shore Hospital, Australia; School of Physics, The University of Sydney, Australia. 3. Department of Radiation Oncology, Calvary Mater Hospital, Newcastle, Australia. 4. Department of Oncology, Aarhus University Hospital, Denmark. 5. Radiation Physics Laboratory, Sydney Medical School, The University of Sydney, Australia; Northern Sydney Cancer Centre, Royal North Shore Hospital, Australia. 6. Northern Sydney Cancer Centre, Royal North Shore Hospital, Australia. 7. Radiation Physics Laboratory, Sydney Medical School, The University of Sydney, Australia. Electronic address: paul.keall@sydney.edu.au.
Abstract
BACKGROUND AND PURPOSE: To perform a quantitative analysis of the accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom (6DoF) prostate motion measurements during treatments. MATERIAL AND METHODS: Real-time 6DoF prostate motion was acquired using KIM for 14 prostate cancer patients (377 fractions). KIM outputs the 6DoF prostate motion, combining 3D translation and 3D rotational motion information relative to its planning position. The corresponding groundtruth target motion was obtained post-treatment based on kV/MV triangulation. The accuracy and precision of the 6DoF KIM motion estimates were calculated as the mean and standard deviation differences compared with the ground-truth. RESULTS: The accuracy ± precision of real-time 6DoF KIM-measured prostate motion were 0.2 ± 1.3° for rotations and 0.1 ± 0.5 mm for translations, respectively. The magnitude of KIM-measured motion was well-correlated with the magnitude of ground-truth motion resulting in Pearson correlation coefficients of ≥0.88 in all DoF. CONCLUSIONS: The results demonstrate that KIM is capable of providing the real-time 6DoF prostate target motion during patient treatments with an accuracy ± precision of within 0.2 ± 1.3° and 0.1 ± 0.5 mm for rotation and translation, respectively. As KIM only requires a single X-ray imager, which is available on most modern cancer radiotherapy devices, there is potential for widespread adoption of this technology.
BACKGROUND AND PURPOSE: To perform a quantitative analysis of the accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom (6DoF) prostate motion measurements during treatments. MATERIAL AND METHODS: Real-time 6DoF prostate motion was acquired using KIM for 14 prostate cancerpatients (377 fractions). KIM outputs the 6DoF prostate motion, combining 3D translation and 3D rotational motion information relative to its planning position. The corresponding groundtruth target motion was obtained post-treatment based on kV/MV triangulation. The accuracy and precision of the 6DoF KIM motion estimates were calculated as the mean and standard deviation differences compared with the ground-truth. RESULTS: The accuracy ± precision of real-time 6DoF KIM-measured prostate motion were 0.2 ± 1.3° for rotations and 0.1 ± 0.5 mm for translations, respectively. The magnitude of KIM-measured motion was well-correlated with the magnitude of ground-truth motion resulting in Pearson correlation coefficients of ≥0.88 in all DoF. CONCLUSIONS: The results demonstrate that KIM is capable of providing the real-time 6DoF prostate target motion during patient treatments with an accuracy ± precision of within 0.2 ± 1.3° and 0.1 ± 0.5 mm for rotation and translation, respectively. As KIM only requires a single X-ray imager, which is available on most modern cancer radiotherapy devices, there is potential for widespread adoption of this technology.
Authors: Wei Zhao; Bin Han; Yong Yang; Mark Buyyounouski; Steven L Hancock; Hilary Bagshaw; Lei Xing Journal: Radiother Oncol Date: 2019-07-11 Impact factor: 6.280