| Literature DB >> 29468590 |
Zhaobin Xu1, Kevin E McElhanon1, Eric X Beck1, Noah Weisleder2.
Abstract
Ligation of the left anterior descending (LAD) coronary artery in the mouse heart is a widely used model to simulate myocardial infarction and ischemia-reperfusion injury. Here we describe a ligation technique routinely performed in our laboratory to induce myocardial infarction that may be used to study ischemia-reperfusion injury in the myocardium. The methods described enhance location of the LAD coronary artery to allow for accurate ligation, thus increasing reproducibility of infarct size and location.Entities:
Keywords: LAD ligation; Left anterior descending coronary artery; Myocardial infarction; Myocardial ischemia–reperfusion; Permanent ligation
Mesh：
Year: 2018 PMID： 29468590 DOI： 10.1007/978-1-4939-7526-6_12
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745