BACKGROUND: Non-compaction of the left ventricle (NCLV) is an unclassified cardiomyopathy due to intrauterine arrest of compaction of the loose interwoven meshwork. Only a few studies involving sub-Saharan Africans insmall numbers have been published. The aim of our study was to determine the diagnostic, therapeutic and prognostic aspects as well as the clinical course of NCLV in a black African population. METHODOLOGY: A multicentre retrospective study was carried out between November 2007 and June 2012 in two cardiology departments in Dakar. Patients who met the echocardiographic criteria for NCLV were included in the study. RESULTS: 35patients with the diagnosis of NCLV were evaluated in the study. Their mean age was 47±18.4 years. Heart failure was found in 77.1% of the patients. The most frequent electrocardiographic abnormalities were left ventricular hypertrophy (LVH) (46%) and sinus tachycardia (43%). Mean non-compaction/compaction ratio was 2.84±0.68 with preferential localization in the apex of the left ventricle. The main complications observed were cardiogenic shock (23.5%), pulmonary embolism (6.3%) and ventricular tachycardia (5.9%). Diuretics and ACE inhibitors were the medications most often prescribed. Age >60 years (p=0.04), male gender (p=0.03) and the occurrence of complications during follow-up (p=0.04) were noted to be predictors of poor prognosis. CONCLUSION: Contrary to previous beliefs, NCLV may not be less common in black Africans than in other ethnic subgroups. Clinicians in Africa should be made aware of NCLV so that it can be diagnosed at earlier stages.
BACKGROUND: Non-compaction of the left ventricle (NCLV) is an unclassified cardiomyopathy due to intrauterine arrest of compaction of the loose interwoven meshwork. Only a few studies involving sub-Saharan Africans insmall numbers have been published. The aim of our study was to determine the diagnostic, therapeutic and prognostic aspects as well as the clinical course of NCLV in a black African population. METHODOLOGY: A multicentre retrospective study was carried out between November 2007 and June 2012 in two cardiology departments in Dakar. Patients who met the echocardiographic criteria for NCLV were included in the study. RESULTS: 35patients with the diagnosis of NCLV were evaluated in the study. Their mean age was 47±18.4 years. Heart failure was found in 77.1% of the patients. The most frequent electrocardiographic abnormalities were left ventricular hypertrophy (LVH) (46%) and sinus tachycardia (43%). Mean non-compaction/compaction ratio was 2.84±0.68 with preferential localization in the apex of the left ventricle. The main complications observed were cardiogenic shock (23.5%), pulmonary embolism (6.3%) and ventricular tachycardia (5.9%). Diuretics and ACE inhibitors were the medications most often prescribed. Age >60 years (p=0.04), male gender (p=0.03) and the occurrence of complications during follow-up (p=0.04) were noted to be predictors of poor prognosis. CONCLUSION: Contrary to previous beliefs, NCLV may not be less common in black Africans than in other ethnic subgroups. Clinicians in Africa should be made aware of NCLV so that it can be diagnosed at earlier stages.
Entities:
Keywords:
Isolated noncompaction of the left ventricular myocardium; Senegal; echocardiography; heart failure
Authors: Ross T Murphy; Rajesh Thaman; Juan Gimeno Blanes; Deirdre Ward; Elias Sevdalis; Efi Papra; Anatoli Kiotsekoglou; Anatoli Kiotsekolglou; Maria T Tome; Denis Pellerin; William J McKenna; Perry M Elliott Journal: Eur Heart J Date: 2004-11-30 Impact factor: 29.983
Authors: Christine H Attenhofer Jost; Heidi M Connolly; Carole A Warnes; Patrick O'leary; A Jamil Tajik; Patricia A Pellikka; James B Seward Journal: J Am Soc Echocardiogr Date: 2004-06 Impact factor: 5.251
Authors: Elham Kayvanpour; Farbod Sedaghat-Hamedani; Weng-Tein Gi; Oguz Firat Tugrul; Ali Amr; Jan Haas; Feng Zhu; Philipp Ehlermann; Lorenz Uhlmann; Hugo A Katus; Benjamin Meder Journal: Clin Res Cardiol Date: 2019-04-12 Impact factor: 5.460
Authors: Nay Aung; Sara Doimo; Fabrizio Ricci; Mihir M Sanghvi; Cesar Pedrosa; Simon P Woodbridge; Amer Al-Balah; Filip Zemrak; Mohammed Y Khanji; Patricia B Munroe; Huseyin Naci; Steffen E Petersen Journal: Circ Cardiovasc Imaging Date: 2020-01-21 Impact factor: 7.792
Authors: Matthew F Yuyun; Aimé Bonny; G André Ng; Karen Sliwa; Andre Pascal Kengne; Ashley Chin; Ana Olga Mocumbi; Marcus Ngantcha; Olujimi A Ajijola; Gene Bukhman Journal: Glob Heart Date: 2020-05-08