| Literature DB >> 29463842 |
Archis Bagati1,2, Anna Bianchi-Smiraglia1, Sudha Moparthy1, Kateryna Kolesnikova1, Emily E Fink1, Masha Kolesnikova1, Matthew V Roll1, Peter Jowdy1, David W Wolff1, Anthony Polechetti1, Dong Hyun Yun1, Brittany C Lipchick1, Leslie M Paul1, Brian Wrazen1, Kalyana Moparthy1, Shaila Mudambi1, Galina E Morozevich3, Sofia G Georgieva4, Jianmin Wang5, Gal Shafirstein1, Song Liu5, Eugene S Kandel1, Albert E Berman3, Neil F Box6, Gyorgy Paragh1,7, Mikhail A Nikiforov8.
Abstract
Oncogenic transcription factor FOXQ1 has been implicated in promotion of multiple transformed phenotypes in carcinoma cells. Recently, we have characterized FOXQ1 as a melanoma tumor suppressor that acts via repression of N-cadherin gene, and invasion and metastasis. Here we report that FOXQ1 induces differentiation in normal and transformed melanocytic cells at least partially via direct transcriptional activation of MITF gene, melanocytic lineage-specific regulator of differentiation. Importantly, we demonstrate that pigmentation induced in cultured melanocytic cells and in mice by activation of cAMP/CREB1 pathway depends in large part on FOXQ1. Moreover, our data reveal that FOXQ1 acts as a critical mediator of BRAFV600E-dependent regulation of MITF levels, thus providing a novel link between two major signal transduction pathways controlling MITF and differentiation in melanocytic cells.Entities:
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Year: 2018 PMID： 29463842 PMCID： PMC5988681 DOI： 10.1038/s41418-018-0066-y
Source DB: PubMed Journal: Cell Death Differ ISSN： 1350-9047 Impact factor: 15.828