Literature DB >> 29462795

Positive zip coding in small protein translocation.

Yukari Okamoto1, Sojin Shikano2.   

Abstract

Most newly synthesized proteins destined for the secretory pathway contain a signal peptide (SP) that triggers cotranslational translocation into the endoplasmic reticulum (ER). However, how small polypeptides undergo ER translocation is not fully understood. In this issue of JBC, Guo et al. describe a mechanism for posttranslational translocation of small secretory proteins featuring a positive charge within the SP N-terminal region. Defects in this element disrupt proper secretion and explain the effects of genetic mutations associated with one type of diabetes.
© 2018 Okamoto and Shikano.

Entities:  

Keywords:  charge; endoplasmic reticulum (ER); positive; posttranslational; ribosome; secretion; signal peptide; signal recognition particle (SRP); translocation

Mesh：

Substances：

Year:  2018        PMID： 29462795      PMCID： PMC5808754          DOI： 10.1074/jbc.H118.001415

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

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