| Literature DB >> 29462286 |
Paul Blanche1, Michael W Kattan2, Thomas A Gerds1.
Abstract
We show that the widely used concordance index for time to event outcome is not proper when interest is in predicting a $t$-year risk of an event, for example 10-year mortality. In the situation with a fixed prediction horizon, the concordance index can be higher for a misspecified model than for a correctly specified model. Impropriety happens because the concordance index assesses the order of the event times and not the order of the event status at the prediction horizon. The time-dependent area under the receiver operating characteristic curve does not have this problem and is proper in this context.Keywords: Concordance index; Cox regression; Discrimination ability; Model comparison; Survival prediction
Mesh:
Year: 2019 PMID: 29462286 DOI: 10.1093/biostatistics/kxy006
Source DB: PubMed Journal: Biostatistics ISSN: 1465-4644 Impact factor: 5.899