Literature DB >> 29462000

Clinical Burdens of β-Thalassemia Major in Affected Children.

Huda Gharaibeh1, Moussa A Barqawi2, Khetam Al-Awamreh3, Mohammed Al Bashtawy4.   

Abstract

BACKGROUND: β-thalassemia major (BTM) is an inherited blood disorder leading to severe anemia. A better understanding of BTM complications can be considered an important factor in developing effective health care provision.
METHOD: A descriptive exploratory design was used to identify the clinical burden of BTM from affected children's perspective. A convenience sample of 45 patients with BTM, accompanied by a family member, was recruited from a governmental hospital during April-May 2015.
RESULTS: The most reported clinical burden was facial deformity 86.9%, followed by systematic infection (48.8%), growth delay (44.4%), and liver problems (39.9%). Patient age was significantly associated with clinical burdens such as bone pain and facial deformity. The number of blood transfusions received was associated with growth delay and bone pain.
CONCLUSION: This study highlights the clinical burdens of thalassemia on affected children, in terms of physical appearance, growth delay and other burdens.

Entities:  

Mesh:

Year:  2018        PMID: 29462000     DOI: 10.1097/MPH.0000000000001104

Source DB:  PubMed          Journal:  J Pediatr Hematol Oncol        ISSN: 1077-4114            Impact factor:   1.289


  3 in total

Review 1.  Luspatercept: A Gigantic Step in the Treatment of Transfusion-Dependent β-Thalassemia Patients-a Quick Review.

Authors:  Hadi Darvishi-Khezri; Hossein Karami
Journal:  Adv Ther       Date:  2021-03-04       Impact factor: 3.845

2.  Molecular characterization of thalassemia and hemoglobinopathy in Southeastern China.

Authors:  Hailong Huang; Liangpu Xu; Meihuan Chen; Na Lin; Huili Xue; Lingji Chen; Yan Wang; Deqin He; Min Zhang; Yuan Lin
Journal:  Sci Rep       Date:  2019-03-05       Impact factor: 4.379

Review 3.  Modified Le Fort I Osteotomy and Genioplasty for Management of Severe Dentofacial Deformity in β-Thalassaemia Major: Case report and review of the literature.

Authors:  Khamis M Al Hasani; Abdulaziz A Bakathir; Ahmed K Al-Hashmi; Badar Al Rawahi; Abdullah Albakri
Journal:  Sultan Qaboos Univ Med J       Date:  2020-10-05
  3 in total

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