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Literature DB >> 29458961

The Genetic/Non-genetic Duality of Drug 'Resistance' in Cancer.

Abstract

Drug resistance is a serious impediment to the treatment of cancer. However, the mechanisms involved remain poorly understood. While it is widely held that the phenomenon is genetic in nature, emerging evidence suggests that non-genetic mechanisms may also be important. Furthermore, at least in some cases, refractoriness to treatment can be reversed by epigenetic reprogramming, and combination and intermittent therapies, as opposed to sustained monotherapy, appear more effective in attenuating it. Here we iterate the confusion in understanding the phenomenon by which cancer cells evade drug response and underscore the need to recognize the genetic/non-genetic duality of drug resistance in cancer. We discuss how ecological and evolutionary principles may help to reconcile the duality and may even offer new treatment strategies.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: cancer; drug resistance; duality; epigenetic mechanism; intermittent therapy

Mesh：

Year: 2018 PMID： 29458961 PMCID： PMC5822736 DOI： 10.1016/j.trecan.2018.01.001

Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025

36 in total

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3. Intrinsically disordered proteins and conformational noise: implications in cancer.

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Authors: Asher Brauner; Ofer Fridman; Orit Gefen; Nathalie Q Balaban
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Authors: Antonija Kreso; John E Dick
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Review 6. Changing Treatment Paradigms in Metastatic Breast Cancer: Lessons Learned.

Authors: Cesar A Santa-Maria; William J Gradishar
Journal: JAMA Oncol Date: 2015-07 Impact factor: 31.777

Review 7. Clonal evolution in cancer.

Authors: Mel Greaves; Carlo C Maley
Journal: Nature Date: 2012-01-18 Impact factor: 49.962

Review 8. The cancer genome.

Authors: Michael R Stratton; Peter J Campbell; P Andrew Futreal
Journal: Nature Date: 2009-04-09 Impact factor: 49.962

Review 9. Combine and conquer: challenges for targeted therapy combinations in early phase trials.

Authors: Juanita S Lopez; Udai Banerji
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Review 10. Fitness and its role in evolutionary genetics.

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68 in total

Review 1. Polytherapy and Targeted Cancer Drug Resistance.

Authors: Nilanjana Chatterjee; Trever G Bivona
Journal: Trends Cancer Date: 2019-02-26

2. Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance.

Authors: Aaron Goldman; Sachin Khiste; Elizaveta Freinkman; Andrew Dhawan; Biswanath Majumder; Jayanta Mondal; Anthony B Pinkerton; Elliot Eton; Ragini Medhi; Vineethkrishna Chandrasekar; M Mamunur Rahman; Takaharu Ichimura; Kodaganur S Gopinath; Pradip Majumder; Mohammad Kohandel; Shiladitya Sengupta
Journal: Sci Signal Date: 2019-08-20 Impact factor: 8.192

The Genetic/Non-genetic Duality of Drug 'Resistance' in Cancer.

Review 1. Phenotypic plasticity and evolution by genetic assimilation.

2. Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing.

3. Intrinsically disordered proteins and conformational noise: implications in cancer.

Review 4. Distinguishing between resistance, tolerance and persistence to antibiotic treatment.

Review 5. Evolution of the cancer stem cell model.

Review 6. Changing Treatment Paradigms in Metastatic Breast Cancer: Lessons Learned.

Review 7. Clonal evolution in cancer.

Review 8. The cancer genome.

Review 9. Combine and conquer: challenges for targeted therapy combinations in early phase trials.

Review 10. Fitness and its role in evolutionary genetics.

Review 1. Polytherapy and Targeted Cancer Drug Resistance.

2. Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance.

Review 3. Emerging role of tumor cell plasticity in modifying therapeutic response.

4. Understanding the role of phenotypic switching in cancer drug resistance.

5. Metabolic cost of rapid adaptation of single yeast cells.

6. A persistent look at how tumours evade therapy.

Review 7. Group Behavior and Emergence of Cancer Drug Resistance.

Review 8. Many Distinct Ways Lead to Drug Resistance in BRAF- and NRAS-Mutated Melanomas.

Review 9. Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer.

Review 10. Does Cancer Biology Rely on Parrondo's Principles?