Literature DB >> 29457749

Chemical and biological studies on Bridelia ferruginea grown in Nigeria.

Michael Afolayan1,2,3, Radhakrishnan Srivedavyasasri1, Olayinka T Asekun2, Oluwole B Familoni2, Samir A Ross1,4.   

Abstract

Phytochemical investigation of the methanolic extract of dried leaves of Bridelia ferruginea led to the isolation and identification of fourteen compounds (1-14): compound 1 [mixture of palmitic, stearic and oleic acids], stearyl monoester of 2-O-β-ᴅ-glucosylglycerol (2), 6β-hydroxy-(20R)-24-ethylcholest-4-en-3-one (3a), 6β-hydroxy-(20R)-24-ethylcholest-4,22-dien-3-one (3b), lutein (4), vomifoliol (5), corilagin (6), kaempferide-3-O-β-ᴅ-glucoside (7), myricetin (8), isomericitrin (9), isoquercetin (10), myricitrin (11), quercitrin (12), rutin (13), and β-sitosterol glucoside (14). The total extract exhibited moderate activity towards CB2 receptor and 90% inhibition against leishmanial pathogen Trypanosoma brucei. Compound 4 exhibited 73% displacement in CB2 receptor with IC50 56.47 μM, and 93% inhibition towards T. brucei with IC50 4.16 μM. Compound 11 showed 99% inhibition towards Escherichia coli with IC50 1.123 μM.

Entities:  

Keywords:  antibacterial; antileishmanial; cannabinoid receptor; flavonoids

Mesh：

Substances：

Year:  2018        PMID： 29457749      PMCID： PMC6098982          DOI： 10.1080/14786419.2018.1440225

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  11 in total

1.  Isolation and structure elucidation of a flavanone, a flavanone glycoside and vomifoliol from Echiochilon fruticosum growing in Tunisia.

Authors:  S Hammami; H Ben Jannet; A Bergaoui; L Ciavatta; G Cimino; Z Mighri
Journal:  Molecules       Date:  2004-06-30       Impact factor: 4.411

2.  Radical scavenging and xanthine oxidase inhibitory activity of phenolic compounds from Bridelia ferruginea stem bark.

Authors:  K Cimanga; L Ying; T De Bruyne; S Apers; P Cos; N Hermans; P Bakana; L Tona; K Kambu; D T Kalenda; L Pieters; D Vanden Berghe; A J Vlietinck
Journal:  J Pharm Pharmacol       Date:  2001-05       Impact factor: 3.765

3.  3-Keto steroids from the marine organisms Dendrophyllia cornigera and Cymodocea nodosa.

Authors:  Ioanna Kontiza; Dennis Abatis; Katerina Malakate; Constantinos Vagias; Vassilios Roussis
Journal:  Steroids       Date:  2005-11-08       Impact factor: 2.668

4.  Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice.

Authors:  O A Olajide; J M Makinde; S O Awe
Journal:  J Ethnopharmacol       Date:  1999-07       Impact factor: 4.360

5.  In vivo antiplasmodial activities of aqueous extract of Bridelia ferruginea stem bark against Plasmodium berghei berghei in mice.

Authors:  Chukwuemeka C Mbah; Godwin C Akuodor; Ngozi A Anyalewechi; Tom C Iwuanyanwu; Uche A Osunkwo
Journal:  Pharm Biol       Date:  2012-02       Impact factor: 3.503

6.  Phosphodiesterase-I inhibitor quinovic acid glycosides from Bridelia ndellensis.

Authors:  M Mostafa; Nilufar Nahar; M Mosihuzzaman; Selestin D Sokeng; Naheed Fatima; M Iqbal Choudhary
Journal:  Nat Prod Res       Date:  2006-06       Impact factor: 2.861

7.  Synthesis of flavonol 3-O-glycoside by UGT78D1.

Authors:  Guangxiang Ren; Jingli Hou; Qinghong Fang; Hong Sun; Xiaoyan Liu; Lianwen Zhang; Peng George Wang
Journal:  Glycoconj J       Date:  2012-07-06       Impact factor: 2.916

8.  Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae).

Authors:  Jeverson Moreira; Luiz Carlos Klein-Júnior; Valdir Cechinel Filho; Fátima de Campos Buzzi
Journal:  J Ethnopharmacol       Date:  2013-01-17       Impact factor: 4.360

9.  Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications.

Authors:  George R Pettit; Justin D Searcy; Rui Tan; Gordon M Cragg; Noeleen Melody; John C Knight; Jean-Charles Chapuis
Journal:  J Nat Prod       Date:  2016-03-03       Impact factor: 4.050

10.  Antimicrobial and selected in vitro enzyme inhibitory effects of leaf extracts, flavonols and indole alkaloids isolated from Croton menyharthii.

Authors:  Mutalib A Aderogba; Ashwell R Ndhlala; Kannan R R Rengasamy; Johannes Van Staden
Journal:  Molecules       Date:  2013-10-11       Impact factor: 4.411
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  2 in total

1.  Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria.

Authors:  Michael Afolayan; Radhakrishnan Srivedavyasasri; Olayinka T Asekun; Oluwole B Familoni; Abayomi Orishadipe; Fazila Zulfiqar; Mohamed A Ibrahim; Samir A Ross
Journal:  Med Chem Res       Date:  2018-08-25       Impact factor: 1.965

2.  Bridelia ferruginea Benth.; An ethnomedicinal, phytochemical, pharmacological and toxicological review.

Authors:  Genevieve Naana Yeboah; Frederick William Akuffo Owusu; Mary-Ann Archer; Michael Odoi Kyene; Doris Kumadoh; Frederick Ayertey; Susana Oteng Mintah; Peter Atta-Adjei Junior; Alfred Ampomah Appiah
Journal:  Heliyon       Date:  2022-08-23
  2 in total

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