Literature DB >> 29454981

Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis.

Andreas Koeberle1, Oliver Werz2.   

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostanoid formation and represent prevalent therapeutics for treatment of inflammatory disorders. However, NSAIDs are afflicted with severe side effects, which might be circumvented by more selective suppression of pro-inflammatory eicosanoid biosynthesis. This concept led to dual inhibitors of microsomal prostaglandin E2 synthase (mPGES)-1 and 5-lipoxygenase that are crucial enzymes in the biosynthesis of pro-inflammatory prostaglandin E2 and leukotrienes. The potential of their dual inhibition in light of superior efficacy and safety is discussed. Focus is placed on natural products, for which direct inhibition of mPGES-1 and leukotriene biosynthesis has been confirmed.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  5-Lipoxygenase; 5-Lipoxygenase-activating protein; Arachidonic acid; Cyclooxygenase; Eicosanoid; Leukotriene; Microsomal prostaglandin E(2) synthase-1; Natural product; Polypharmacology; Prostaglandin

Mesh：

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Year:  2018        PMID： 29454981     DOI： 10.1016/j.biotechadv.2018.02.010

Source DB:  PubMed          Journal:  Biotechnol Adv        ISSN： 0734-9750            Impact factor:   14.227


  10 in total

1.  Plectranthus zeylanicus: A Rich Source of Secondary Metabolites with Antimicrobial, Disinfectant and Anti-Inflammatory Activities.

Authors:  Mayuri Napagoda; Jana Gerstmeier; Hannah Butschek; Sybille Lorenz; Sudhara De Soyza; Mallique Qader; Ajith Nagahawatte; Gaya Bandara Wijayaratne; Bernd Schneider; Aleš Svatoš; Lalith Jayasinghe; Andreas Koeberle; Oliver Werz
Journal:  Pharmaceuticals (Basel)       Date:  2022-03-31

2.  The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka.

Authors:  Mayuri Napagoda; Jana Gerstmeier; Hannah Butschek; Sudhara De Soyza; Simona Pace; Sybille Lorenz; Mallique Qader; Sanjeeva Witharana; Ajith Nagahawatte; Gaya Wijayaratne; Aleš Svatoš; Lalith Jayasinghe; Andreas Koeberle; Oliver Werz
Journal:  Molecules       Date:  2020-04-20       Impact factor: 4.411

3.  Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity.

Authors:  Blerina Shkodra-Pula; Christian Kretzer; Paul M Jordan; Paul Klemm; Andreas Koeberle; David Pretzel; Erden Banoglu; Stefan Lorkowski; Maria Wallert; Stephanie Höppener; Steffi Stumpf; Antje Vollrath; Stephanie Schubert; Oliver Werz; Ulrich S Schubert
Journal:  J Nanobiotechnology       Date:  2020-05-14       Impact factor: 10.435

Review 4.  Applications of the Pharmacophore Concept in Natural Product inspired Drug Design.

Authors:  Thomas Seidel; Oliver Wieder; Arthur Garon; Thierry Langer
Journal:  Mol Inform       Date:  2020-07-09       Impact factor: 3.353

5.  Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201.

Authors:  Christian Kretzer; Paul M Jordan; Rossella Bilancia; Antonietta Rossi; Tuğçe Gür Maz; Erden Banoglu; Ulrich S Schubert; Oliver Werz
Journal:  J Inflamm Res       Date:  2022-02-09

6.  Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood.

Authors:  Christian Kretzer; Blerina Shkodra; Paul Klemm; Paul M Jordan; Daniel Schröder; Gizem Cinar; Antje Vollrath; Stephanie Schubert; Ivo Nischang; Stephanie Hoeppener; Steffi Stumpf; Erden Banoglu; Frederike Gladigau; Rossella Bilancia; Antonietta Rossi; Christian Eggeling; Ute Neugebauer; Ulrich S Schubert; Oliver Werz
Journal:  Cell Mol Life Sci       Date:  2021-12-31       Impact factor: 9.261

7.  In Vitro Hypoglycemic and Anti-Inflammatory Potential and Toxicity of Powders from Pulp and by-Products of Ziziphus mistol from Argentina.

Authors:  María Eugenia Orqueda; Sebastian Torres; Iris Catiana Zampini; María Inés Isla
Journal:  Foods       Date:  2022-07-18

8.  From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution.

Authors:  Tran Thi Van Anh; Alilou Mostafa; Zhigang Rao; Simona Pace; Stefan Schwaiger; Christian Kretzer; Veronika Temml; Carsten Giesel; Paul M Jordan; Rossella Bilancia; Christina Weinigel; Silke Rummler; Birgit Waltenberger; Tran Hung; Antonietta Rossi; Hermann Stuppner; Oliver Werz; Andreas Koeberle
Journal:  Acta Pharm Sin B       Date:  2021-04-20       Impact factor: 11.413

9.  In Silico, In Vitro, and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway.

Authors:  Anella Saviano; Simona De Vita; Maria Giovanna Chini; Noemi Marigliano; Gianluigi Lauro; Gian Marco Casillo; Federica Raucci; Maria Iorizzi; Robert Klaus Hofstetter; Katrin Fischer; Andreas Koeberle; Oliver Werz; Francesco Maione; Giuseppe Bifulco
Journal:  Biomolecules       Date:  2022-01-07

10.  Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design.

Authors:  Lukas Friedrich; Gino Cingolani; Ying-Hui Ko; Mariaclara Iaselli; Morena Miciaccia; Maria Grazia Perrone; Konstantin Neukirch; Veronika Bobinger; Daniel Merk; Robert Klaus Hofstetter; Oliver Werz; Andreas Koeberle; Antonio Scilimati; Gisbert Schneider
Journal:  Adv Sci (Weinh)       Date:  2021-06-27       Impact factor: 16.806
  10 in total

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