Literature DB >> 2944863

Selective suppression by prodigiosin of the mitogenic response of murine splenocytes.

A Nakamura, K Nagai, K Ando, G Tamura.   

Abstract

In the course of screening for immunomodulating substances among microbial metabolites using a triple mitogen assay system, we detected an immunosuppressive activity which is similar to cyclosporin A. Two active components were isolated as red pigments from the fermentation broth of Streptomyces hiroshimensis and they were identified with prodigiosin 25-C and metacycloprodigiosin respectively. These compounds inhibited T lymphocyte proliferation which was induced by plant lectins, concanavalin A (Con A) and phytohemagglutinin (PHA), much more extensively than B lymphocyte proliferation which was induced by lipopolysaccharide (LPS). Prodigiosin 25-C completely inhibited induction of cytotoxic T cells in a mixed lymphocyte reaction (MLR) at 4 ng/ml.

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Year:  1986        PMID： 2944863     DOI： 10.7164/antibiotics.39.1155

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  9 in total

1.  E5531, a synthetic non-toxic lipid A derivative blocks the immunobiological activities of lipopolysaccharide.

Authors:  T Kawata; J R Bristol; D P Rossignol; J R Rose; S Kobayashi; H Yokohama; A Ishibashi; W J Christ; K Katayama; I Yamatsu; Y Kishi
Journal:  Br J Pharmacol       Date:  1999-06       Impact factor: 8.739

Review 2.  Immunomodulators isolated from microorganisms.

Authors:  Z Vanĕk; J Matĕjů; E Curdová
Journal:  Folia Microbiol (Praha)       Date:  1991       Impact factor: 2.099

3.  Prodigiosins uncouple lysosomal vacuolar-type ATPase through promotion of H+/Cl- symport.

Authors:  S Ohkuma; T Sato; M Okamoto; H Matsuya; K Arai; T Kataoka; K Nagai; H H Wasserman
Journal:  Biochem J       Date:  1998-09-15       Impact factor: 3.857

4.  In vivo rapid reduction of alloantigen-activated CD8+ mature cytotoxic T cells by inhibitors of acidification of intracellular organelles, prodigiosin 25-C and concanamycin B.

Authors:  M H Lee; T Kataoka; N Honjo; J Magae; K Nagai
Journal:  Immunology       Date:  2000-02       Impact factor: 7.397

5.  Potent in vitro antimalarial activity of metacycloprodigiosin isolated from Streptomyces spectabilis BCC 4785.

Authors:  Masahiko Isaka; Amonlaya Jaturapat; Jarin Kramyu; Morakot Tanticharoen; Yodhathai Thebtaranonth
Journal:  Antimicrob Agents Chemother       Date:  2002-04       Impact factor: 5.191

6.  Induction of Inflammatory Responses in Splenocytes by Exosomes Released from Intestinal Epithelial Cells following Cryptosporidium parvum Infection.

Authors:  Yang Wang; Yujuan Shen; Hua Liu; Jianhai Yin; Xin-Tian Zhang; Ai-Yu Gong; Xiqiang Chen; Siyi Chen; Nicholas W Mathy; Jianping Cao; Xian-Ming Chen
Journal:  Infect Immun       Date:  2019-03-25       Impact factor: 3.441

Review 7.  Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage.

Authors:  Patrick C Still; Tyler A Johnson; Christine M Theodore; Steven T Loveridge; Phillip Crews
Journal:  J Nat Prod       Date:  2014-02-26       Impact factor: 4.050

Review 8.  Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products.

Authors:  Dennis X Hu; David M Withall; Gregory L Challis; Regan J Thomson
Journal:  Chem Rev       Date:  2016-06-17       Impact factor: 60.622

9.  Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues and conversion to antimalarial premarineosins via a Rieske oxygenase catalyzed bicyclization.

Authors:  Papireddy Kancharla; Wanli Lu; Shaimaa M Salem; Jane Xu Kelly; Kevin A Reynolds
Journal:  J Org Chem       Date:  2014-11-18       Impact factor: 4.354
  9 in total

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