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Literature DB >> 11897600

Potent in vitro antimalarial activity of metacycloprodigiosin isolated from Streptomyces spectabilis BCC 4785.

Masahiko Isaka¹, Amonlaya Jaturapat, Jarin Kramyu, Morakot Tanticharoen, Yodhathai Thebtaranonth.

Abstract

Bioassay-guided fractionation of the extract from the fermentation broth of Streptomyces spectabilis BCC 4785 led to the isolation of three principle antimalarial agents, metacycloprodigiosin, bafilomycin A(1), and spectinabilin. Metacycloprodigiosin exhibited potent in vitro activity against Plasmodium falciparum K1, with a 50% inhibitory concentration of 0.0050 +/- 0.0010 microg/ml, while its cytotoxicity was much weaker.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2002 PMID： 11897600 PMCID： PMC127104 DOI： 10.1128/AAC.46.4.1112-1113.2002

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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