| Literature DB >> 2944480 |
S L Spruance, D J Freeman, N V Sheth.
Abstract
Topical foscarnet (PFA) and acyclovir (ACV) were compared in the dorsal cutaneous guinea pig model of herpes simplex virus type 1 infection. The relative order of efficacy was PFA cream greater than ACV cream greater than ACV ointment. In vitro studies demonstrated that PFA and ACV formulated in cream vehicles penetrated through guinea pig skin 7- to 10-fold faster than did ACV in ointment.Entities:
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Year: 1986 PMID: 2944480 PMCID: PMC176467 DOI: 10.1128/AAC.30.1.196
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191