Literature DB >> 29443293

Pediatric epilepsy: Five new things.

Kelly Knupp1, Susan Koh1, Kristen Park1.   

Abstract

Epilepsy in children can be very different from epilepsy in adults, both in seizure type and epilepsy syndrome. The goal in treating children is seizure freedom, no treatment side effects, and function that is no different from the general population. In a significant percentage of patients, this goal remains unachievable, but many aspects of epilepsy are becoming clearer. This review will highlight 5 areas where progress is being made to achieve these goals in pediatric epilepsy. Specific research animal models are being developed to reflect the unique features of different pediatric epilepsies. As genetic syndromes are better identified, for some patients this has led to improved treatment. New advances in drug therapy have led to 3 new medications approved for children. More effective drug choices can now be recommended due to comparative drug trials and better overall care of children can be provided due to awareness of the comorbidities of epilepsy.

Entities:  

Year:  2012        PMID: 29443293      PMCID: PMC5766023          DOI: 10.1212/CPJ.0b013e31824c6cbd

Source DB:  PubMed          Journal:  Neurol Clin Pract        ISSN: 2163-0402


  43 in total

1.  De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy.

Authors:  L Claes; J Del-Favero; B Ceulemans; L Lagae; C Van Broeckhoven; P De Jonghe
Journal:  Am J Hum Genet       Date:  2001-05-15       Impact factor: 11.025

2.  The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trial.

Authors:  Andrew L Lux; Stuart W Edwards; Eleanor Hancock; Anthony L Johnson; Colin R Kennedy; Richard W Newton; Finbar J K O'Callaghan; Christopher M Verity; John P Osborne
Journal:  Lancet       Date:  2004 Nov 13-19       Impact factor: 79.321

3.  Idiopathic generalized epilepsy with generalized tonic-clonic seizures (IGE-GTC): a population-based cohort with >20 year follow up for medical and social outcome.

Authors:  Peter Camfield; Carol Camfield
Journal:  Epilepsy Behav       Date:  2010-05-14       Impact factor: 2.937

Review 4.  Vitamin D and bone health among children with epilepsy.

Authors:  Renée A Shellhaas; Sucheta M Joshi
Journal:  Pediatr Neurol       Date:  2010-06       Impact factor: 3.372

5.  Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala.

Authors:  T Z Baram; E Hirsch; O C Snead; L Schultz
Journal:  Ann Neurol       Date:  1992-05       Impact factor: 10.422

6.  Outcomes of childhood epilepsy at age 33 years: a population-based birth-cohort study.

Authors:  Richard F M Chin; Phillippa M Cumberland; Suresh S Pujar; Catherine Peckham; Euan M Ross; Rod C Scott
Journal:  Epilepsia       Date:  2011-07-18       Impact factor: 5.864

Review 7.  Analysis of genetically complex epilepsies.

Authors:  Ruth Ottman
Journal:  Epilepsia       Date:  2005       Impact factor: 5.864

8.  Vigabatrin-induced peripheral visual field defects in patients with refractory partial epilepsy.

Authors:  Robert C Sergott; Richard M Bittman; Erin M Christen; Stephen M Sagar
Journal:  Epilepsy Res       Date:  2010-10-15       Impact factor: 3.045

Review 9.  How do the many etiologies of West syndrome lead to excitability and seizures? The corticotropin releasing hormone excess hypothesis.

Authors:  K L Brunson; M Eghbal-Ahmadi; T Z Baram
Journal:  Brain Dev       Date:  2001-11       Impact factor: 1.961

10.  The spectrum of SCN1A-related infantile epileptic encephalopathies.

Authors:  Louise A Harkin; Jacinta M McMahon; Xenia Iona; Leanne Dibbens; James T Pelekanos; Sameer M Zuberi; Lynette G Sadleir; Eva Andermann; Deepak Gill; Kevin Farrell; Mary Connolly; Thorsten Stanley; Michael Harbord; Frederick Andermann; Jing Wang; Sat Dev Batish; Jeffrey G Jones; William K Seltzer; Alison Gardner; Grant Sutherland; Samuel F Berkovic; John C Mulley; Ingrid E Scheffer
Journal:  Brain       Date:  2007-03       Impact factor: 13.501

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  1 in total

1.  Over 10-Year Outcomes of Infantile-Onset Epilepsies.

Authors:  Hyun-Jin Kim; Han Na Jang; Hyunji Ahn; Mi-Sun Yum; Tae-Sung Ko
Journal:  J Clin Med       Date:  2021-01-22       Impact factor: 4.241

  1 in total

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