J Knox1, V Pedoia2, A Wang3, M Tanaka4, G B Joseph5, J Neumann6, T M Link7, X Li8, C B Ma9. 1. University of California San Francisco School of Medicine, UCSF, San Francisco, CA, USA. Electronic address: joseph.knox@ucsf.edu. 2. Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, USA. Electronic address: Valentina.Pedoia@ucsf.edu. 3. Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, USA. Electronic address: Amy.Wang@ucsf.edu. 4. Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, USA. Electronic address: Matthew.Tanaka@ucsf.edu. 5. Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, USA. Electronic address: Gabby.Joseph@ucsf.edu. 6. Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, USA. Electronic address: Jan.Neumann@ucsf.edu. 7. Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, USA. Electronic address: Thomas.Link@ucsf.edu. 8. Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, USA. Electronic address: Xiaojuan.Li@ucsf.edu. 9. Department of Orthopaedic Surgery, UCSF, San Francisco, CA, USA. Electronic address: MaBen@ucsf.edu.
Abstract
OBJECTIVE: To evaluate the longitudinal changes in meniscal T1ρ/T2 signal post-reconstruction in patients with acute anterior cruciate ligament (ACL) injury and to investigate the association with T1ρ/T2 signal in articular knee cartilage. METHOD: In this prospective study, knees of 37 patients with ACL-injury and reconstruction in addition to 13 healthy controls were scanned using magnetic resonance imaging (MRI) T1ρ/T2 mapping. Quantitative analysis of the meniscus was performed in the anterior/posterior horns of lateral/medial meniscus fourteen sub-compartments of cartilage spanning the medial/lateral area of the tibia and femoral condyles. Meniscus T1ρ/T2 signals were compared between injured, contralateral and control knees at baseline, 6-months, 1-year and 2-years using t-tests for cross-sectional comparisons and a mixed model for longitudinal comparisons. Pearson-partial correlations between meniscal and cartilage T1ρ/T2 were evaluated. RESULTS: There was a significant decrease of T1ρ/T2 signal in the posterior horn of lateral meniscus (PHLAT) of injured knees during a 2-year period. In the posterior horn of medial meniscus (PHMED), T1ρ/T2 signal of injured knees was significantly elevated at all time points post-reconstruction compared to contralateral and control knees. Within injured knees, PHMED T1ρ/T2 signal showed significant positive correlations with medial tibia (MT) cartilage T1ρ/T2 signal at all time points. CONCLUSION: A significant decrease in PHLAT T1ρ/T2 signal by 2-years suggests potential tissue recovery after ACL-injury. Elevated T1ρ/T2 signal in the PHMED of injured knees at 2-years correlating with knee cartilage T1ρ/T2 signal elevations suggests involvement of the PHMED in subacute cartilage degeneration after ACL-injury and reconstruction.
OBJECTIVE: To evaluate the longitudinal changes in meniscal T1ρ/T2 signal post-reconstruction in patients with acute anterior cruciate ligament (ACL) injury and to investigate the association with T1ρ/T2 signal in articular knee cartilage. METHOD: In this prospective study, knees of 37 patients with ACL-injury and reconstruction in addition to 13 healthy controls were scanned using magnetic resonance imaging (MRI) T1ρ/T2 mapping. Quantitative analysis of the meniscus was performed in the anterior/posterior horns of lateral/medial meniscus fourteen sub-compartments of cartilage spanning the medial/lateral area of the tibia and femoral condyles. Meniscus T1ρ/T2 signals were compared between injured, contralateral and control knees at baseline, 6-months, 1-year and 2-years using t-tests for cross-sectional comparisons and a mixed model for longitudinal comparisons. Pearson-partial correlations between meniscal and cartilage T1ρ/T2 were evaluated. RESULTS: There was a significant decrease of T1ρ/T2 signal in the posterior horn of lateral meniscus (PHLAT) of injured knees during a 2-year period. In the posterior horn of medial meniscus (PHMED), T1ρ/T2 signal of injured knees was significantly elevated at all time points post-reconstruction compared to contralateral and control knees. Within injured knees, PHMED T1ρ/T2 signal showed significant positive correlations with medial tibia (MT) cartilage T1ρ/T2 signal at all time points. CONCLUSION: A significant decrease in PHLAT T1ρ/T2 signal by 2-years suggests potential tissue recovery after ACL-injury. Elevated T1ρ/T2 signal in the PHMED of injured knees at 2-years correlating with knee cartilage T1ρ/T2 signal elevations suggests involvement of the PHMED in subacute cartilage degeneration after ACL-injury and reconstruction.
Authors: A K Lange; M A Fiatarone Singh; R M Smith; N Foroughi; M K Baker; R Shnier; B Vanwanseele Journal: Osteoarthritis Cartilage Date: 2007-01-03 Impact factor: 6.576
Authors: Stefan Klein; Marius Staring; Keelin Murphy; Max A Viergever; Josien P W Pluim Journal: IEEE Trans Med Imaging Date: 2009-11-17 Impact factor: 10.048
Authors: X Li; C Benjamin Ma; T M Link; D-D Castillo; G Blumenkrantz; J Lozano; J Carballido-Gamio; M Ries; S Majumdar Journal: Osteoarthritis Cartilage Date: 2007-02-16 Impact factor: 6.576
Authors: Hu Na; Zhang Yan; Sheng Min; Wu Zhi-hong; Jin Jin; Bao Fei; Meng Wei; Xu Jin; Jiang Bo; Liu Dong; Jin Zheng-yu Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao Date: 2011-04
Authors: Isabel Rauscher; Robert Stahl; Jonathan Cheng; Xiaojuan Li; Markus B Huber; Anthony Luke; Sharmila Majumdar; Thomas M Link Journal: Radiology Date: 2008-11 Impact factor: 11.105
Authors: Matthias J Feucht; Sebastian Bigdon; Gerrit Bode; Gian M Salzmann; David Dovi-Akue; Norbert P Südkamp; Philipp Niemeyer Journal: J Orthop Surg Res Date: 2015-03-18 Impact factor: 2.359
Authors: Sean W Flannery; Ata M Kiapour; David J Edgar; Martha M Murray; Jillian E Beveridge; Braden C Fleming Journal: J Orthop Res Date: 2021-01-27 Impact factor: 3.494
Authors: Susanne M Eijgenraam; Akshay S Chaudhari; Max Reijman; Sita M A Bierma-Zeinstra; Brian A Hargreaves; Jos Runhaar; Frank W J Heijboer; Garry E Gold; Edwin H G Oei Journal: Eur Radiol Date: 2019-12-16 Impact factor: 5.315