| Literature DB >> 29429059 |
Fengyan Bao1, Ruotian Tang2, Li Cheng1, Cuiyun Zhang1, Chongyue Qiu1, Ting Yuan1, Lihan Zhu1, Hua Li3,4, Lixia Chen5.
Abstract
A new diterpenoid glucoside, (3S,5S,6S,8R,9R,10S)-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3-O-β-D-glucopyranoside (1), and a new iridoid glucoside, (1S, 5S,6R,9R)-10-O-p-hydroxybenzoyl-5,6β-dihydroxy iridoid 1-O-β-D-glucopyranoside (2), along with six known compounds (3-8) were isolated from Vitex trifolia L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds 2, 4, 5, and 7 showed moderate inhibitory activities with IC50 values of 90.05, 88.51, 87.26, and 76.06 μM, respectively.Entities:
Keywords: Anti-inflammatory effect; Diterpenoid; Iridoid; Vitex trifolia L.
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Year: 2018 PMID： 29429059 DOI： 10.1007/s11418-018-1178-x
Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343