Literature DB >> 29428365

The mechanisms linking obesity to colon cancer: An overview.

Aleksandra Tarasiuk1, Paula Mosińska1, Jakub Fichna2.   

Abstract

Obesity, characterised as a chronic low-grade inflammation is a crucial risk factor for colon cancer. The expansion of the adipose tissue is related to elevated triglyceride and low-density lipoprotein (LDL) levels and hyperinsulinemia, which all are presumed mediators of the tumour development. Obesity is also believed to support carcinogenesis by activating the insulin/IGF-1 pathway. Moreover, obesity increases the level of proinflammatory cytokines (e.g. TNF-α, IL-1, and IL-6) and has a significant impact on selected adipokines. This paper briefly outlines the latest evidence of the linkage between the obesity and colon cancer and discusses its possible implication for the improvement of anticancer prevention and treatment strategies connected with nutrition.
Copyright © 2018 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Adipose tissue; Colon cancer; Obesity; Proinflammatory cytokines

Mesh：

Substances：

Year:  2018        PMID： 29428365     DOI： 10.1016/j.orcp.2018.01.005

Source DB:  PubMed          Journal:  Obes Res Clin Pract        ISSN： 1871-403X            Impact factor:   2.288


  10 in total

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4.  Transcriptome Profiles of Human Visceral Adipocytes in Obesity and Colorectal Cancer Unravel the Effects of Body Mass Index and Polyunsaturated Fatty Acids on Genes and Biological Processes Related to Tumorigenesis.

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5.  Association between heavy metals and colon cancer: an ecological study based on geographical information systems in North-Eastern Iran.

Authors:  Hadi Rahimzadeh; Benyamin Hoseini; Behzad Kiani; Fatemeh Hashemi Amin; Nasser Bagheri; Robert Bergquist; Ali Akbar Mohammadi; Mahmood Yousefi; Hossein Faraji; Gholamreza Roshandel; Somayeh Beirami
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Review 6.  Altered Adipokine Expression in Tumor Microenvironment Promotes Development of Triple Negative Breast Cancer.

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10.  Azoxymethane Alters the Plasma Metabolome to a Greater Extent in Mice Fed a High-Fat Diet Compared to an AIN-93 Diet.

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  10 in total

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