Hualiang Lin1, Zhengmin Min Qian2, Yanfei Guo3, Yang Zheng3, Siqi Ai1, Jian Hang4, Xiaojie Wang5, Lingli Zhang5, Tao Liu5, Weijie Guan6, Xing Li5, Jianpeng Xiao5, Weilin Zeng5, Hong Xian2, Steven W Howard2, Wenjun Ma7, Fan Wu8. 1. Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China. 2. College for Public Health & Social Justice, Saint Louis University, St. Louis, MO, USA. 3. Shanghai Municipal Centre for Disease Control and Prevention, Shanghai, China. 4. School of Atmospheric Sciences, Sun Yat-sen University, Guangzhou, China. 5. Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. 6. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China. 7. Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. Electronic address: mawj@gdiph.org.cn. 8. Shanghai Municipal Centre for Disease Control and Prevention, Shanghai, China. Electronic address: wufan@scdc.sh.cn.
Abstract
BACKGROUND: The linkage between ambient fine particle pollution (PM2.5) and chronic obstructive pulmonary disease (COPD) and the attributable risk remained largely unknown. This study determined the cross-sectional association between ambient PM2.5 and prevalence of COPD among adults ≥50 years of age. METHODS: We surveyed 29,290 participants aged 50 years and above in this study. The annual average concentrations of PM2.5 derived from satellite data were used as the exposure indicator. A mixed effect model was applied to determine the associations and the burden of COPD attributable to PM2.5. RESULTS: Among the participants, 1872 (6.39%) were classified as COPD cases. Our analysis observed a threshold concentration of 30 μg/m3 in the PM2.5-COPD association, above which we found a linear positive exposure-response association between ambient PM2.5 and COPD. The odds ratio (OR) for each 10 μg/m3 increase in ambient PM2.5 was 1.21(95% CI: 1.13, 1.30). Stratified analyses suggested that males, older subjects (65 years and older) and those with lower education attainment might be the vulnerable subpopulations. We further estimated that about 13.79% (95% CI: 7.82%, 21.62%) of the COPD cases could be attributable to PM2.5 levels higher than 30 μg/m3 in the study population. CONCLUSION: Our analysis indicates that ambient PM2.5 exposure could increase the risk of COPD and accounts for a substantial fraction of COPD among the study population.
BACKGROUND: The linkage between ambient fine particle pollution (PM2.5) and chronic obstructive pulmonary disease (COPD) and the attributable risk remained largely unknown. This study determined the cross-sectional association between ambient PM2.5 and prevalence of COPD among adults ≥50 years of age. METHODS: We surveyed 29,290 participants aged 50 years and above in this study. The annual average concentrations of PM2.5 derived from satellite data were used as the exposure indicator. A mixed effect model was applied to determine the associations and the burden of COPD attributable to PM2.5. RESULTS: Among the participants, 1872 (6.39%) were classified as COPD cases. Our analysis observed a threshold concentration of 30 μg/m3 in the PM2.5-COPD association, above which we found a linear positive exposure-response association between ambient PM2.5 and COPD. The odds ratio (OR) for each 10 μg/m3 increase in ambient PM2.5 was 1.21(95% CI: 1.13, 1.30). Stratified analyses suggested that males, older subjects (65 years and older) and those with lower education attainment might be the vulnerable subpopulations. We further estimated that about 13.79% (95% CI: 7.82%, 21.62%) of the COPD cases could be attributable to PM2.5 levels higher than 30 μg/m3 in the study population. CONCLUSION: Our analysis indicates that ambient PM2.5 exposure could increase the risk of COPD and accounts for a substantial fraction of COPD among the study population.
Authors: Philip J Landrigan; Samantha Fisher; Maureen E Kenny; Brittney Gedeon; Luke Bryan; Jenna Mu; David Bellinger Journal: Environ Health Date: 2022-07-18 Impact factor: 7.123