Antonio García-Hermoso1, Iván Cavero-Redondo2, Robinson Ramírez-Vélez3, Jonatan R Ruiz4, Francisco B Ortega4, Duck-Chul Lee5, Vicente Martínez-Vizcaíno6. 1. Laboratorio de Ciencias de la Actividad Física, el Deporte y la Salud, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, USACH, Santiago, Chile. Electronic address: antonio.garcia.h@usach.cl. 2. Universidad de Castilla-La Mancha. Health and Social Research Center, Cuenca, Spain. 3. Centro de Estudios en Medición de la Actividad Física (CEMA), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, D.C, Colombia. 4. PROFITH (PROmoting FITness and Health through physical activity) research group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Spain. 5. Department of Kinesiology, College of Human Sciences, Iowa State University, Ames, USA. 6. Universidad de Castilla-La Mancha. Health and Social Research Center, Cuenca, Spain; Universidad Autónoma de Chile, Facultad de Ciencias de la Salud, Talca, Chile.
Abstract
OBJECTIVES: The aims of the present systematic review and meta-analysis were to determine the relationship between muscular strength and all-cause mortality risk and to examine the sex-specific impact of muscular strength on all-cause mortality in an apparently healthy population. DATA SOURCES: Two authors systematically searched MEDLINE, EMBASE and SPORTDiscus databases and conducted manual searching of reference lists of selected articles. STUDY SELECTION: Eligible cohort studies were those that examined the association of muscular strength with all-cause mortality in an apparently healthy population. The hazard ratio (HR) estimates with 95% confidence interval (CI) were pooled by using random effects meta-analysis models after assessing heterogeneity across studies. DATA EXTRACTION: Two authors independently extracted data. DATA SYNTHESIS: Thirty-eight studies with 1,907,580 participants were included in the meta-analysis. The included studies had a total of 63,087 deaths. Higher levels of handgrip strength were associated with a reduced risk of all-cause mortality (HR=0.69; 95% CI, 0.64-0.74) compared with lower muscular strength, with a slightly stronger association in women (HR=0.60; 95% CI, 0.51-0.69) than men (HR=0.69; 95% CI, 0.62-0.77) (all P<.001). Also, adults with higher levels of muscular strength, as assessed by knee extension strength test, had a 14% lower risk of death (HR=0.86: 95% CI, 0.80-0.93; P<.001) compared with adults with lower muscular strength. CONCLUSIONS: Higher levels of upper- and lower-body muscular strength are associated with a lower risk of mortality in adult population, regardless of age and follow-up period. Muscular strength tests can be easily performed to identify people with lower muscular strength and, consequently, with an increased risk of mortality.
OBJECTIVES: The aims of the present systematic review and meta-analysis were to determine the relationship between muscular strength and all-cause mortality risk and to examine the sex-specific impact of muscular strength on all-cause mortality in an apparently healthy population. DATA SOURCES: Two authors systematically searched MEDLINE, EMBASE and SPORTDiscus databases and conducted manual searching of reference lists of selected articles. STUDY SELECTION: Eligible cohort studies were those that examined the association of muscular strength with all-cause mortality in an apparently healthy population. The hazard ratio (HR) estimates with 95% confidence interval (CI) were pooled by using random effects meta-analysis models after assessing heterogeneity across studies. DATA EXTRACTION: Two authors independently extracted data. DATA SYNTHESIS: Thirty-eight studies with 1,907,580 participants were included in the meta-analysis. The included studies had a total of 63,087 deaths. Higher levels of handgrip strength were associated with a reduced risk of all-cause mortality (HR=0.69; 95% CI, 0.64-0.74) compared with lower muscular strength, with a slightly stronger association in women (HR=0.60; 95% CI, 0.51-0.69) than men (HR=0.69; 95% CI, 0.62-0.77) (all P<.001). Also, adults with higher levels of muscular strength, as assessed by knee extension strength test, had a 14% lower risk of death (HR=0.86: 95% CI, 0.80-0.93; P<.001) compared with adults with lower muscular strength. CONCLUSIONS: Higher levels of upper- and lower-body muscular strength are associated with a lower risk of mortality in adult population, regardless of age and follow-up period. Muscular strength tests can be easily performed to identify people with lower muscular strength and, consequently, with an increased risk of mortality.
Authors: Augustine W Kang; Carol Ewing Garber; Charles B Eaton; Patricia M Risica; Andrew G Bostom Journal: Med Sci Sports Exerc Date: 2019-06 Impact factor: 5.411
Authors: Alana L Andrade-Guimarães; Manuel H Aguiar-Oliveira; Roberto Salvatori; Vitor O Carvalho; Fabiano Alvim-Pereira; Carlos R Araújo Daniel; Giulliani A Moreira Brasileiro; Ananda A Santana-Ribeiro; Hugo A Santos-Carvalho; Carla R P Oliveira; Edgar R Vieira; Miburge B Gois-Junior Journal: Endocrine Date: 2018-09-24 Impact factor: 3.633
Authors: Marzo E Da Silva-Grigoletto; Marceli M A Mesquita; José C Aragão-Santos; Marta S Santos; Antônio G Resende-Neto; Josimari M de Santana; David G Behm Journal: J Sports Sci Med Date: 2019-11-19 Impact factor: 2.988
Authors: Julie A Karabinus; Jacob P DeBlois; Allison Keller; Alaina C Glasgow; Tiago V Barreira; Kevin S Heffernan Journal: Int J Sports Med Date: 2020-09-13 Impact factor: 3.118