Jiu-Yang Liu1, Chun-Wei Peng1, Xiao-Jun Yang1, Chao-Qun Huang1, Yan Li1,2. 1. Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study CenterNo. 169 Donghu Road, Wuchang District, Wuhan 430071, P. R. China. 2. Department of Peritoneal Cancer Surgery, Cancer Center of Beijing Shijitan Hospital Affiliated to The Capital Medical UniversityNo. 10 Tieyi Road, Yangfangdian, Beijing 100038, P. R. China.
Abstract
OBJECTIVE: The present study was designed to investigate whether AJCC/UICC 8th edition staging system precisely differentiated patients with different prognosis of gastric cancer (GC). METHODS: There were 540 GC cases included in this study. Stratification was done according to the 7th and 8th AJCC/UICC tumor-node-metastasis (TNM) staging systems. Detailed comparison was conducted between two editions in terms of the sub-classification of pN3 stage, redefinitions of stage III, homogeneity, discrimination power, predictive accuracy, and complexity. RESULTS: Compared to the 7th edition, the 8th TNM staging system performed better by incorporating pN3a and pN3b into the final stage of GC (P<0.001), had better stage grouping homogeneity (P<0.001), prognostic value (area under the curve, AUC-value was 0.809), and comparable discrimination power. CONCLUSIONS: AJCC 8th TNM staging system showed improved efficiency in GC prognosis.
OBJECTIVE: The present study was designed to investigate whether AJCC/UICC 8th edition staging system precisely differentiated patients with different prognosis of gastric cancer (GC). METHODS: There were 540 GC cases included in this study. Stratification was done according to the 7th and 8th AJCC/UICC tumor-node-metastasis (TNM) staging systems. Detailed comparison was conducted between two editions in terms of the sub-classification of pN3 stage, redefinitions of stage III, homogeneity, discrimination power, predictive accuracy, and complexity. RESULTS: Compared to the 7th edition, the 8th TNM staging system performed better by incorporating pN3a and pN3b into the final stage of GC (P<0.001), had better stage grouping homogeneity (P<0.001), prognostic value (area under the curve, AUC-value was 0.809), and comparable discrimination power. CONCLUSIONS: AJCC 8th TNM staging system showed improved efficiency in GC prognosis.
Entities:
Keywords:
AJCC; Gastric cancer; prognosis; staging system
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