Sir,I read with interest the study by Rahimi et al. on the demographic and clinical features of pediatric uveitis at a tertiary referral center in Iran.[1] The authors mentioned that noninfectious uveitis was detected in 81.5% of the studied patients compared to 18.5% for infectious uveitis. Among the infectious category, there were four patients with toxocariasis, four patients with toxoplasmosis, and one patient with herpes simplex virus infection.[1] Interestingly, no case of human immunodeficiency virus (HIV)-associated uveitis was reported. It is obvious that HIV infection is one of the twenty- first century's biggest global challenges to humankind with wide manifestations affecting all organs of our body, including eyes. It has been reported that there was a 52%–100% lifetime accumulative risk of HIV-positivepatients developing various ocular problems. Seventy-seven percent of patients with ocular manifestations of HIV infection have been noticed to have CD4 counts <200 cells/μL.[2] In an interesting Thailand study, intraocular HIV-1 RNA was detected in 32% of HIV-positivepatients with uveitis. Intraocular HIV-1 RNA loads were associated with high-HIV-1 RNA plasma loads (P < 0.001) and not being on highly active antiretroviral therapy (P = 0.005). In addition, detectable intraocular HIV-1 RNA levels were found to be higher in patients with the absence of retinal lesions (P = 0.008). In 7% of HIV-positivepatients, the HIV load in the eye largely exceeded that of plasma.[3] Although no recent data on the exact prevalence of HIV infection in the pediatric population are yet present in Iran, the available data pointed out that the overall HIV rates in Iran have generally increased by 80% per year for the past decade.[4] It was not clearly evident in the methodology of Rahimi et al.'s study[1] that HIV infection was considered in the studied cohort through appropriate workp of CD4 count and viral overload measurements. Hence, I presume that the actual rate of pediatric HIV-associated uveitis might be underestimated.