OBJECTIVE: The objective of this study was to analyze human immunodeficiency virus (HIV) dynamics across the blood-retinal barrier and to determine whether the high levels of HIV in the eye are associated with any ocular disorders in HIV-infected patients. DESIGN: This study included a prospective case series of 40 HIV-positive patients with uveitis. INTERVENTION: Clinical and laboratory examinations included plasma and intraocular HIV-1 RNA loads as well as the clinical manifestations of uveitis. RESULTS: Intraocular HIV-1 RNA was detected in 32% (13/40) of HIV-positive patients with uveitis. Intraocular HIV-1 RNA loads were associated with high HIV-1 RNA plasma loads (P < 0.001) and not being on HAART therapy (P = 0.005). In addition, detectable intraocular HIV-1 RNA levels were higher in patients with the absence of retinal lesions (P = 0.008). In three patients, the HIV load in the eye largely exceeded that of plasma. These three patients had all bilateral anterior uveitis and/or vitritis without retinal lesions and exhibited no evidence of other intraocular infectious agents causing uveitis than HIV itself. CONCLUSION: The eye can form a sanctuary where HIV might replicate and cause an inflammatory reaction.
OBJECTIVE: The objective of this study was to analyze human immunodeficiency virus (HIV) dynamics across the blood-retinal barrier and to determine whether the high levels of HIV in the eye are associated with any ocular disorders in HIV-infectedpatients. DESIGN: This study included a prospective case series of 40 HIV-positivepatients with uveitis. INTERVENTION: Clinical and laboratory examinations included plasma and intraocular HIV-1 RNA loads as well as the clinical manifestations of uveitis. RESULTS:Intraocular HIV-1 RNA was detected in 32% (13/40) of HIV-positivepatients with uveitis. Intraocular HIV-1 RNA loads were associated with high HIV-1 RNA plasma loads (P < 0.001) and not being on HAART therapy (P = 0.005). In addition, detectable intraocular HIV-1 RNA levels were higher in patients with the absence of retinal lesions (P = 0.008). In three patients, the HIV load in the eye largely exceeded that of plasma. These three patients had all bilateral anterior uveitis and/or vitritis without retinal lesions and exhibited no evidence of other intraocular infectious agents causing uveitis than HIV itself. CONCLUSION: The eye can form a sanctuary where HIV might replicate and cause an inflammatory reaction.
Authors: Corey A Williams-Wietzikoski; Isaac D So; Marta E Bull; Tanawan Samleerat; Kessara Pathanapitoon; Paradee Kunavisarut; Natedao Kongyai; Nicole Ngo-Giang-Huong; Lisa M Frenkel; Wasna Sirirungsi Journal: AIDS Date: 2017-08-24 Impact factor: 4.177
Authors: Sophia Pathai; Stephen D Lawn; Paul G Shiels; Helen A Weiss; Colin Cook; Robin Wood; Clare E Gilbert Journal: PLoS One Date: 2013-02-27 Impact factor: 3.240
Authors: Jayapratha R Selvaraj; S Sudharshan; Lily K Therese; M K Janani; Poongulali Selvamuthu; Parveen Rewri; Jyotirmay Biswas Journal: Indian J Ophthalmol Date: 2018-11 Impact factor: 1.848