Alex P Di Battista1,2, Shawn G Rhind2,3, Andrew J Baker1,4,5, Rakesh Jetly6,7, Jeff D Debad8, Doug Richards3, Michael G Hutchison3,5. 1. a Institute of Medical Science, University of Toronto , Toronto , ON , Canada. 2. b Defence Research and Development Canada, Toronto Research Centre , Toronto , ON , Canada. 3. c Faculty of Kinesiology & Physical Education , University of Toronto , Toronto , ON , Canada. 4. d Departments of Critical Care , Anesthesia and Surgery, St. Michael's Hospital, University of Toronto , Toronto ON , Canada. 5. e Neuroscience Program, Keenan Research Centre for Biomedical Science of St. Michael's Hospital , Toronto , ON , Canada. 6. f Directorate of Mental Health , Canadian Forces Health Services , Ottawa , ON Canada. 7. g Department of Psychiatry , University of Ottawa , Ottawa , ON , Canada. 8. h Meso Scale Diagnostics, LLC ., Rockville , MD , USA.
Abstract
OBJECTIVES: To characterise a panel of neuroinjury-related blood biomarkers after sport-related concussion (SRC). We hypothesised significant differences in biomarker profiles between athletes with SRC and healthy controls at both subacute and medical clearance time points. METHODS: Thirty-eight interuniversity athletes were recruited over two athletic seasons (n = 19 SRC; n = 19 healthy matched-control). High-sensitivity immunoassay was used to evaluate 11 blood analytes at both the subacute phase after SRC and at medical clearance. RESULTS: Univariate analysis identified elevated circulating peroxiredoxin-6 (PRDX-6) in athletes with SRC compared to healthy controls at the subacute time point. Multivariate analyses yielded similar results in the subacute phase, but identified both PRDX-6 and T-tau as significant contributors to class separation between athletes with SRC and controls at medical clearance. CONCLUSIONS: Our results are consistent with the increasing recognition that physiological recovery after SRC extends beyond clinical recovery. Blood biomarkers appear to be useful in elucidating the biology of brain restitution after SRC. However, their implementation requires mindfulness of factors such as academic stress, exercise, and injury heterogeneity.
OBJECTIVES: To characterise a panel of neuroinjury-related blood biomarkers after sport-related concussion (SRC). We hypothesised significant differences in biomarker profiles between athletes with SRC and healthy controls at both subacute and medical clearance time points. METHODS: Thirty-eight interuniversity athletes were recruited over two athletic seasons (n = 19 SRC; n = 19 healthy matched-control). High-sensitivity immunoassay was used to evaluate 11 blood analytes at both the subacute phase after SRC and at medical clearance. RESULTS: Univariate analysis identified elevated circulating peroxiredoxin-6 (PRDX-6) in athletes with SRC compared to healthy controls at the subacute time point. Multivariate analyses yielded similar results in the subacute phase, but identified both PRDX-6 and T-tau as significant contributors to class separation between athletes with SRC and controls at medical clearance. CONCLUSIONS: Our results are consistent with the increasing recognition that physiological recovery after SRC extends beyond clinical recovery. Blood biomarkers appear to be useful in elucidating the biology of brain restitution after SRC. However, their implementation requires mindfulness of factors such as academic stress, exercise, and injury heterogeneity.
Authors: Jamie Kearns; Aisling M Ross; Darragh R Walsh; Rachel M Cahalane; Rita Hinchion; Maria C Ryan; Elaine Conway; Tom M Comyns; Ian C Kenny; Eibhlís M O'Connor; Kieran D McGourty; John Joseph Eugene Mulvihill Journal: BMJ Open Sport Exerc Med Date: 2020-11-26
Authors: Alex P Di Battista; Katherine A Moes; Maria Y Shiu; Michael G Hutchison; Nathan Churchill; Scott G Thomas; Shawn G Rhind Journal: Front Physiol Date: 2018-09-28 Impact factor: 4.566
Authors: Alex P Di Battista; Nathan Churchill; Shawn G Rhind; Doug Richards; Michael G Hutchison Journal: BMC Immunol Date: 2020-03-12 Impact factor: 3.615
Authors: Alex P Di Battista; Shawn G Rhind; Nathan Churchill; Doug Richards; David W Lawrence; Michael G Hutchison Journal: Sci Rep Date: 2019-12-09 Impact factor: 4.379
Authors: Oshin Vartanian; Catherine Tenn; Shawn G Rhind; Ann Nakashima; Alex P Di Battista; Lauren E Sergio; Diana J Gorbet; Douglas D Fraser; Angela Colantonio; Kristen King; Quan Lam; Doug Saunders; Rakesh Jetly Journal: Front Neurol Date: 2020-12-03 Impact factor: 4.003
Authors: Alex P Di Battista; Nathan Churchill; Shawn G Rhind; Doug Richards; Michael G Hutchison Journal: J Neuroinflammation Date: 2019-01-26 Impact factor: 8.322