Literature DB >> 34013449

The Roles of Peroxiredoxin 6 in Brain Diseases.

Jiangfeng Liao1,2, Yusi Zhang1,2, Xiaochun Chen3,4, Jing Zhang5,6.   

Abstract

Peroxiredoxin 6 (PRDX6), the only mammalian 1-Cys member of the peroxiredoxins (PRDXs) family, has multiple functions of glutathione peroxidase (Gpx) activity, acidic calcium-independent phospholipase (aiPLA2) activity, and lysophosphatidylcholine acyl transferase (LPCAT) activity. It has been documented to be involved in redox homeostasis, phospholipid turnover, glycolipid metabolism, and cellular signaling. Here, we reviewed the characteristics of the available Prdx6 genetic mouse models and the research progresses made with regard to PRDX6 in neuropsychiatric disorders, including neurodegenerative diseases, brain aging, stroke, neurotrauma, gliomas, major depressive disorder, drug addiction, post-traumatic stress disorder, and schizophrenia. The present review highlights the important roles of PRDX6 in neuropsychiatric disorders and may provide novel insights for the development of effective pharmacological treatments and genetic therapies.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Knockdown; Neuropsychiatric disorders; Overexpression; Peroxiredoxin 6

Mesh：

Substances：

Year:  2021        PMID： 34013449     DOI： 10.1007/s12035-021-02427-5

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  120 in total

1.  Peroxiredoxin distribution in the mouse brain with emphasis on neuronal populations affected in neurodegenerative disorders.

Authors:  Julie Goemaere; Bernard Knoops
Journal:  J Comp Neurol       Date:  2012-02-01       Impact factor: 3.215

Review 2.  Lipid rafts and neurodegeneration: structural and functional roles in physiologic aging and neurodegenerative diseases.

Authors:  Sara Grassi; Paola Giussani; Laura Mauri; Simona Prioni; Sandro Sonnino; Alessandro Prinetti
Journal:  J Lipid Res       Date:  2019-12-23       Impact factor: 5.922

3.  Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain.

Authors:  Takashi Shichita; Eiichi Hasegawa; Akihiro Kimura; Rimpei Morita; Ryota Sakaguchi; Ichiro Takada; Takashi Sekiya; Hiroaki Ooboshi; Takanari Kitazono; Toru Yanagawa; Tetsuro Ishii; Hideo Takahashi; Shuji Mori; Masahiro Nishibori; Kazumichi Kuroda; Shizuo Akira; Kensuke Miyake; Akihiko Yoshimura
Journal:  Nat Med       Date:  2012-06       Impact factor: 53.440

Review 4.  Phospholipase A2 and its role in brain tissue.

Authors:  A A Farooqui; H C Yang; T A Rosenberger; L A Horrocks
Journal:  J Neurochem       Date:  1997-09       Impact factor: 5.372

5.  Acceleration of the development of Alzheimer's disease in amyloid beta-infused peroxiredoxin 6 overexpression transgenic mice.

Authors:  Hyung-Mun Yun; Peng Jin; Jin-Yi Han; Moon-Soon Lee; Sang-Bae Han; Ki-Wan Oh; Sung-Han Hong; Eun-Yong Jung; Jin Tae Hong
Journal:  Mol Neurobiol       Date:  2013-06-15       Impact factor: 5.590

6.  A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6.

Authors:  Aron B Fisher; Chandra Dodia; Elena M Sorokina; Haitao Li; Suiping Zhou; Tobias Raabe; Sheldon I Feinstein
Journal:  J Lipid Res       Date:  2016-02-01       Impact factor: 5.922

7.  Phospholipase A2 of Peroxiredoxin 6 Plays a Critical Role in Cerebral Ischemia/Reperfusion Inflammatory Injury.

Authors:  Yu Shanshan; Jiang Beibei; Tan Li; Gao Minna; Lei Shipeng; Peng Li; Zhao Yong
Journal:  Front Cell Neurosci       Date:  2017-04-05       Impact factor: 5.505

8.  PRDX6 Inhibits Neurogenesis through Downregulation of WDFY1-Mediated TLR4 Signal.

Authors:  In Jun Yeo; Mi Hee Park; Dong Ju Son; Ji Young Kim; Kyoung Tak Nam; Byung Kook Hyun; So Young Kim; Myung Hee Jung; Min Ji Song; Hyung Ok Chun; Tae Hyung Lee; Sang-Bae Han; Jin Tae Hong
Journal:  Mol Neurobiol       Date:  2018-08-10       Impact factor: 5.590

9.  Peroxiredoxin 6 in human brain: molecular forms, cellular distribution and association with Alzheimer's disease pathology.

Authors:  John H T Power; Sana Asad; Tim K Chataway; Fariba Chegini; James Manavis; James A Temlett; Poul H Jensen; Peter C Blumbergs; Wei-Ping Gai
Journal:  Acta Neuropathol       Date:  2008-04-02       Impact factor: 17.088
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  5 in total

Review 1.  The role of Toll-like receptors and neuroinflammation in Parkinson's disease.

Authors:  Arash Heidari; Niloufar Yazdanpanah; Nima Rezaei
Journal:  J Neuroinflammation       Date:  2022-06-06       Impact factor: 9.587

2.  Tackling the Biological Meaning of the Human Olfactory Bulb Dyshomeostatic Proteome across Neurological Disorders: An Integrative Bioinformatic Approach.

Authors:  Paz Cartas-Cejudo; Mercedes Lachén-Montes; Joaquín Fernández-Irigoyen; Enrique Santamaría
Journal:  Int J Mol Sci       Date:  2021-10-20       Impact factor: 5.923

3.  Peroxiredoxin 6 mediates the protective function of curcumin pretreatment in acute lung injury induced by serum from patients undergoing one-lung ventilation in vitro.

Authors:  Hui-Ting Li; Fang Tan; Tian-Hua Zhang; Long-Hui Cao; Hong-Ying Tan; Wen-Qian Lin; Wei-An Zeng; Xin-Jin Chi
Journal:  BMC Pulm Med       Date:  2022-05-12       Impact factor: 3.320

4.  Selenocysteine Machinery Primarily Supports TXNRD1 and GPX4 Functions and Together They Are Functionally Linked with SCD and PRDX6.

Authors:  Didac Santesmasses; Vadim N Gladyshev
Journal:  Biomolecules       Date:  2022-07-28

5.  PRDX6: A protein bridging S-palmitoylation and diabetic neuropathy.

Authors:  Yan Cao; Wantao Wang; Xiaorong Zhan; Yitong Zhang
Journal:  Front Endocrinol (Lausanne)       Date:  2022-09-02       Impact factor: 6.055
  5 in total

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