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Literature DB >> 2941358

Ciprofloxacin for treating urethral gonorrhoea in men.

M Shahmanesh, S R Shukla, I Phillips, A Westwood, R N Thin.

Abstract

The effectiveness of a single oral dose of ciprofloxacin in eradicating urethral gonorrhoea was assessed in 18 men who received 250 mg and 26 men who were given 100 mg. All patients, including two infected with beta lactamase (penicillinase) producing strains of Neisseria gonorrhoeae (PPNG), were cured. The drug had no effect on infection with Chlamydia trachomatis or on the incidence of post gonococcal urethritis. Ciprofloxacin may be useful in patients hypersensitive to penicillins and cephalosporins, and the drug may also be useful in urethral gonorrhoea caused by PPNG strains.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1986 PMID： 2941358 PMCID： PMC1011905 DOI： 10.1136/sti.62.2.86

Source DB: PubMed Journal: Genitourin Med ISSN： 0266-4348

4 in total

1. Diagnosis of gonorrhoea by culture on a selective medium containing vancomycin, colistin, nystatin and trimethoprim (VCNT). A comparison with Gram-staining and immunofluorescence.

Authors: I Phillips; D Humphrey; A Middleton; C S Nicol
Journal: Br J Vener Dis Date: 1972-08

2. Changes in the pharmacokinetics of ciprofloxacin and fecal flora during administration of a 7-day course to human volunteers.

Authors: W Brumfitt; I Franklin; D Grady; J M Hamilton-Miller; A Iliffe
Journal: Antimicrob Agents Chemother Date: 1984-11 Impact factor: 5.191

3. Beta-lactamase-producing, penicillin-resistant gonococcus.

Authors: I Phillips
Journal: Lancet Date: 1976-09-25 Impact factor: 79.321

4. Pharmacokinetics of ciprofloxacin after oral and intravenous administration in healthy volunteers.

Authors: W Wingender; K H Graefe; W Gau; D Förster; D Beermann; P Schacht
Journal: Eur J Clin Microbiol Date: 1984-08 Impact factor: 3.267

4 in total

10 in total

1. Comparison of ofloxacin and ceftriaxone in the treatment of uncomplicated gonorrhea caused by penicillinase-producing and non-penicillinase-producing strains.

Authors: J M Covino; M Cummings; B Smith; S Benes; K Draft; W M McCormack
Journal: Antimicrob Agents Chemother Date: 1990-01 Impact factor: 5.191

Review 2. Treatment of genitourinary tract infections with fluoroquinolones: clinical efficacy in genital infections and adverse effects.

Authors: D C Hooper; J S Wolfson
Journal: Antimicrob Agents Chemother Date: 1989-10 Impact factor: 5.191

Ciprofloxacin for treating urethral gonorrhoea in men.

1. Diagnosis of gonorrhoea by culture on a selective medium containing vancomycin, colistin, nystatin and trimethoprim (VCNT). A comparison with Gram-staining and immunofluorescence.

2. Changes in the pharmacokinetics of ciprofloxacin and fecal flora during administration of a 7-day course to human volunteers.

3. Beta-lactamase-producing, penicillin-resistant gonococcus.

4. Pharmacokinetics of ciprofloxacin after oral and intravenous administration in healthy volunteers.

1. Comparison of ofloxacin and ceftriaxone in the treatment of uncomplicated gonorrhea caused by penicillinase-producing and non-penicillinase-producing strains.

Review 2. Treatment of genitourinary tract infections with fluoroquinolones: clinical efficacy in genital infections and adverse effects.

3. Quinolones in non-gonococcal urethritis.

4. Quinolones in the treatment of gonorrhoea and Chlamydia trachomatis infections.

5. Comparison of ciprofloxacin and ceftriaxone as single-dose therapy for uncomplicated gonorrhea in women.

6. Ciprofloxacin treatment of chlamydial infections of urogenital tracts of women.

7. Pefloxacin and ciprofloxacin in the treatment of uncomplicated gonococcal urethritis in males [corrected].

Review 8. Ciprofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

9. Enoxacin as one day oral treatment of men with anal or pharyngeal gonorrhoea.

Review 10. Fluoroquinolone antimicrobial agents.