Takuji Iyama1, Tomoaki Takata2, Masahiko Koda1, Satoko Fukuda1, Shotaro Hoi1, Yukari Mae1, Takeaki Fukui1, Chishio Munemura1, Hajime Isomoto1. 1. Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, Tottori University, 36-1 Nishimachi, Yonago, Tottori, 683-8504, Japan. 2. Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, Tottori University, 36-1 Nishimachi, Yonago, Tottori, 683-8504, Japan. t-takata@med.tottori-u.ac.jp.
Abstract
PURPOSE: To investigate the association of renal elasticity to microscopic findings of nephron hypertrophy and nephrosclerosis. METHODS: Patients who underwent renal biopsy were enrolled. Renal elasticity was measured by acoustic radiation force impulse, and nephron size (glomerular volume, non-sclerotic glomerular density, and mean profile tubular area) and nephrosclerosis (globally sclerotic glomeruli and interstitial fibrosis) were estimated. Nephron hypertrophy was indicated by larger glomerular volume, larger tubular area, and lower non-sclerotic glomerular density. Nephrosclerosis was indicated by a higher percentage of globally sclerotic glomeruli and higher severity of fibrosis. RESULTS: Renal elasticity was negatively correlated with glomerular volume (r = - 0.480, P = 0.024) and mean tubular area (r = - 0.469, P = 0.028), but it was not correlated with non-sclerotic glomerular density (r = 0.205, P = 0.359), percentage of globally sclerotic glomeruli (r = 0.057, P = 0.800), and severity of fibrosis (r = 0.014, P = 0.950). In a multiple linear regression analysis, glomerular volume and mean tubular area were independently associated with renal elasticity (std β = - 0.454, P = 0.015 and std β = - 0.577, P = 0.007, respectively). CONCLUSION: Renal elasticity was correlated with microstructural findings of nephron hypertrophy. Measuring renal elasticity could help in detecting kidney disease.
PURPOSE: To investigate the association of renal elasticity to microscopic findings of nephron hypertrophy and nephrosclerosis. METHODS:Patients who underwent renal biopsy were enrolled. Renal elasticity was measured by acoustic radiation force impulse, and nephron size (glomerular volume, non-sclerotic glomerular density, and mean profile tubular area) and nephrosclerosis (globally sclerotic glomeruli and interstitial fibrosis) were estimated. Nephron hypertrophy was indicated by larger glomerular volume, larger tubular area, and lower non-sclerotic glomerular density. Nephrosclerosis was indicated by a higher percentage of globally sclerotic glomeruli and higher severity of fibrosis. RESULTS: Renal elasticity was negatively correlated with glomerular volume (r = - 0.480, P = 0.024) and mean tubular area (r = - 0.469, P = 0.028), but it was not correlated with non-sclerotic glomerular density (r = 0.205, P = 0.359), percentage of globally sclerotic glomeruli (r = 0.057, P = 0.800), and severity of fibrosis (r = 0.014, P = 0.950). In a multiple linear regression analysis, glomerular volume and mean tubular area were independently associated with renal elasticity (std β = - 0.454, P = 0.015 and std β = - 0.577, P = 0.007, respectively). CONCLUSION: Renal elasticity was correlated with microstructural findings of nephron hypertrophy. Measuring renal elasticity could help in detecting kidney disease.
Authors: Hisham E Elsherbiny; Mariam P Alexander; Walter K Kremers; Walter D Park; Emilio D Poggio; Mikel Prieto; John C Lieske; Andrew D Rule Journal: Clin J Am Soc Nephrol Date: 2014-10-15 Impact factor: 8.237
Authors: Aleksandar Denic; Mariam P Alexander; Vidhu Kaushik; Lilach O Lerman; John C Lieske; Mark D Stegall; Joseph J Larson; Walter K Kremers; Terri J Vrtiska; Harini A Chakkera; Emilio D Poggio; Andrew D Rule Journal: Am J Kidney Dis Date: 2016-02-06 Impact factor: 8.860
Authors: Ana Tobar; Yaacov Ori; Sydney Benchetrit; Gai Milo; Michal Herman-Edelstein; Boris Zingerman; Netta Lev; Uzi Gafter; Avry Chagnac Journal: PLoS One Date: 2013-09-25 Impact factor: 3.240