Jorge Enrique Gómez Marín1, Juan David Zuluaga2, Eunice Julied Pechené Campo2, Jessica Triviño2, Alejandra de-la-Torre3. 1. Grupo de Estudio en Parasitología Molecular (GEPAMOL), Centro de Investigaciones Biomédicas, Universidad del Quindío, Armenia, Colombia; Grupo de Investigación en Población Infantil (IPI), Hospital Universitario San Juan de Dios, Armenia, Colombia. 2. Grupo de Estudio en Parasitología Molecular (GEPAMOL), Centro de Investigaciones Biomédicas, Universidad del Quindío, Armenia, Colombia. 3. Grupo de Estudio en Parasitología Molecular (GEPAMOL), Centro de Investigaciones Biomédicas, Universidad del Quindío, Armenia, Colombia; Grupo de Investigación en Neurociencias (NeURos), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia. Electronic address: ligia.delatorre@urosario.edu.co.
Abstract
INTRODUCTION: Cases of toxoplasmosis present in South America tend to be more severe than that found in other continents. Here, we present our clinical experience of ocular and ganglionar toxoplasmosis in the use of PCR, and of the treatment to prevent ocular involvement. METHODOLOGY: Retrospective analysis of clinical charts of patients with ocular and lymphadenitic toxoplasmosis at the parasitology and tropical medicine consultation in the "Universidad del Quindio" in Colombia. In total, 91 records of cases with ocular toxoplasmosis and 17 with lymphadenitis that underwent PCR analysis for B1 repeated sequence in blood, were compared to the results of 104 people with chronic asymptomatic toxoplasmosis. In addition, 41 clinical records were included from patients with confirmed toxoplasmic lymphadenitis: 10 untreated, 6 that begun treatment after four months of symptoms, and 25 that were treated during the first four months of symptoms and had a follow-up during at least one year. RESULTS: Patients with ocular toxoplasmosis or lymphadenitis had a higher probability of PCR positivity in peripheral blood than chronic asymptomatic people. There were no cases of retinochoroiditis in 25 patients with toxoplasmic lymphadenitis treated before 4 months of symptoms and followed during at least 12 months. In four out of ten untreated cases, new lesions of retinochoroiditis presented after the symptoms of lymphadenitis. CONCLUSIONS: Toxoplasmosisin South America exhibits different clinical behavior and this influences the laboratory results as well as the need for treatment in the case of lymphadenitis. Clinicians should be aware of the geographical origin of the infection in order to adopt different therapeutic and diagnostic approaches.
INTRODUCTION: Cases of toxoplasmosis present in South America tend to be more severe than that found in other continents. Here, we present our clinical experience of ocular and ganglionar toxoplasmosis in the use of PCR, and of the treatment to prevent ocular involvement. METHODOLOGY: Retrospective analysis of clinical charts of patients with ocular and lymphadenitic toxoplasmosis at the parasitology and tropical medicine consultation in the "Universidad del Quindio" in Colombia. In total, 91 records of cases with ocular toxoplasmosis and 17 with lymphadenitis that underwent PCR analysis for B1 repeated sequence in blood, were compared to the results of 104 people with chronic asymptomatic toxoplasmosis. In addition, 41 clinical records were included from patients with confirmed toxoplasmic lymphadenitis: 10 untreated, 6 that begun treatment after four months of symptoms, and 25 that were treated during the first four months of symptoms and had a follow-up during at least one year. RESULTS:Patients with ocular toxoplasmosis or lymphadenitis had a higher probability of PCR positivity in peripheral blood than chronic asymptomatic people. There were no cases of retinochoroiditis in 25 patients with toxoplasmic lymphadenitis treated before 4 months of symptoms and followed during at least 12 months. In four out of ten untreated cases, new lesions of retinochoroiditis presented after the symptoms of lymphadenitis. CONCLUSIONS: Toxoplasmosisin South America exhibits different clinical behavior and this influences the laboratory results as well as the need for treatment in the case of lymphadenitis. Clinicians should be aware of the geographical origin of the infection in order to adopt different therapeutic and diagnostic approaches.
Authors: Juan David Medina Hernández; Laura Alejandra Osorio Delgado; Daniel Zabala Gonzalez; Ricardo Wagner De Almeida Vitor; Jorge Enrique Gómez; Julio César Carranza; Gustavo Adolfo Vallejo Journal: Biomedica Date: 2022-03-01 Impact factor: 1.173
Authors: Jorge Enrique Gómez-Marín; Juliana Muñoz-Ortiz; Manuela Mejía-Oquendo; José Y Arteaga-Rivera; Nicolás Rivera-Valdivia; María Cristina Bohórquez-Granados; Stefany Velasco-Velásquez; Gabriela Castaño-de-la-Torre; John Alejandro Acosta-Dávila; Laura Lorena García-López; Elizabeth Torres-Morales; Mónica Vargas; Juan David Valencia; Daniel Celis-Giraldo; Alejandra de-la-Torre Journal: Heliyon Date: 2021-04-05
Authors: Alejandra de-la-Torre; Juanita Valdés-Camacho; Clara López de Mesa; Andrés Uauy-Nazal; Juan David Zuluaga; Lina María Ramírez-Páez; Felipe Durán; Elizabeth Torres-Morales; Jessica Triviño; Mateo Murillo; Alba Cristina Peñaranda; Juan Carlos Sepúlveda-Arias; Jorge Enrique Gómez-Marín Journal: BMC Infect Dis Date: 2019-01-25 Impact factor: 3.090